Evidence map›Paper›PMID 40264430›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2025

The Adverse Influence of Maternal Glycaemia During Pregnancy on Offspring's Cardiometabolic Health Profiles.

Wen Lun Yuan, Aminata H Cissé, Muriel Tafflet, Elissa El Khoury, Olfa Khalfallah, Laetitia Davidovic, Marie Aline Charles, Barbara Heude

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In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wen Lun YuanUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France.ORCID 0000-0002-7472-5042
Aminata H CisséUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France.
Muriel TaffletUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France.
Elissa El KhouryUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France.
Olfa KhalfallahInstitut de Pharmacologie Moléculaire et Cellulaire, CNRS, INSERM, Université Nice Côte d'Azur, UMR7275, UMR_S, Valbonne, France.
Laetitia DavidovicInstitut de Pharmacologie Moléculaire et Cellulaire, CNRS, INSERM, Université Nice Côte d'Azur, UMR7275, UMR_S, Valbonne, France.
Marie Aline CharlesUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France.
Barbara HeudeUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France.

Funding

Diabetes National Research ProgramEuropean Union's Horizon 2020 research and innovation program 874739Fondation de FranceFoundation for Medical Research (FRM)French Agency for Environmental Health SafetyFrench Ministry of Health (DGS)French Ministry of Research, Inserm Bone and Joint Diseases National Research (PRO-A) and Human Nutrition National Research Programmes, Paris-Sud University, Nestlé, French National Institute for Population Health Surveillance (InVS)French National Agency for Food Security and the French-speaking association for the study of diabetes and metabolism (ALFEDIAM)French National Institute for Health Education (INPES)Mutuelle Générale de l'Education Nationale (MGEN)National Agency for Research (ANR)National Institute for Research in Public Health (IRESP: TGIR cohorte santé 2008 program)the European Union FP7 programs FP7/2007-2013
6 · The paper itself

Abstract

aimTo describe cardiometabolic health profiles at age 5-6 years, their correlation with age at adiposity rebound (AR) and associations with maternal hyperglycaemia at 24-28 weeks' gestation (gestational diabetes, fasting (FPG), 1-hour postload plasma glucose), in mothers without pre-existing diabetes.

methodsBMI, %fat mass, blood pressure (BP), FPG, HOMA-IR and lipids were assessed in children from the EDEN study, a French bicentric birth cohort. Sex-specific cardiometabolic health profiles were derived using principal component analysis and examined against age at AR with Pearson's correlation. Associations with maternal hyperglycaemia were studied using multiple linear regressions adjusted for parental factors.

resultsAmong 674 children, four profiles were identified per sex: 'higher adiposity, BP, insulin resistance (IR)'; 'higher BP and lower adiposity'; 'higher IR and lower adiposity'; 'higher triglycerides and LDL-c and lower HDL-c'. The profile of 'higher adiposity, BP, IR' was correlated with earlier age at AR in both sexes. Higher maternal FPG was positively associated with the profile of 'higher adiposity, BP, IR' in boys and 'higher triglycerides and LDL-c and lower HDL-c' in girls.

conclusion'Higher adiposity, BP, IR' profile at age 5-6 years was associated with earlier age of adiposity rebound. Marginal associations were observed with maternal hyperglycaemia in pregnancy.

Indexed as

Diabetes, GestationalHyperglycemiaPrenatal Exposure Delayed EffectsAdiposityBlood GlucoseBlood PressureChildChild, PreschoolFemaleHumansMalePregnancyBlood Glucoseadiposity reboundcardiometabolic healthchildrengestational diabetes mellitusgestational glycaemia

Identifiers

PMID40264430
PMCPMC12336935

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.