ArticleDiabetes, obesity & metabolism2025
Long-term adherence to glucose-lowering medications in adults with diabetes: A data linkage study.
Article in Diabetes, obesity & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Long-term adherence to glucose-lowering therapy and cardiovascular risk in type 2 diabetes: a nationwide cohort study.The Lancet regional health. Europe · 2026Article
- Long-term adherence to glucose-lowering medications in adults with diabetes: A data linkage study.Diabetes, obesity & metabolism · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
aimsTo determine the adherence rate in users of each class of glucose-lowering medication and identify the key socio-demographic factors influencing adherence.
methodsThe 45 and Up Study is an ongoing cohort study of residents aged ≥45 years in New South Wales, Australia. We analysed Pharmaceutical Benefits Scheme records from 2013 to 2019 of the 21 341 study participants who self-reported having diabetes. Medication adherence was estimated as the proportion of days covered for each 12-month period for up to the fifth 12-month period.
resultsA consistent pattern was observed across all drug classes, where the percentage of adherent (proportion of days covered ≥0.8) users was highest in the first 12 months, followed by a drop in the second 12 months. For prevalent users on the same drug class for the full 5-year period, higher percentages of adherent users compared to the first 12 months were observed for glucagon-like peptide 1 receptor agonists (77.7% vs 74.2%). For incident users on the same drug class for the full 5-year period, a higher percentage of adherent users compared to the first 12 months was observed for sodium-glucose cotransporter 2 inhibitors (84.2% vs 78.4%). Moreover, no socio-demographic subgroup was consistently more or less adherent to medications.
conclusionsInitial adherence was good and remained relatively high over time in this cohort. Nevertheless, adherence was still a challenge in some individuals. Practitioners should recognize the possibility of non-adherence and consider this at each consultation.
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