ArticleCurrent pharmaceutical design2025
Mechanism of Sour Jujube Kernel-five-flavour Berry in the Treatment of Insomnia based on Network Pharmacology and Molecular Docking.
Article in Current pharmaceutical design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Research Progress on Pharmacological Effects of Key Pharmacodynamic Material Basis Components ofJournal of microbiology and biotechnology · 2026Review
- The Development and Optimisation of a Spinosin Solid-Dispersion-Based Functional Dairy Beverage and Its Sleep-Promoting Effects in Mice.Foods (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe incidence of insomnia is increasing annually worldwide. Most Western tranquilisers have side effects, such as strong dependence and notable withdrawal reactions. The sour jujube kernel and five-flavour berry can calm the mind and improve sleep, but the underlying mechanism is still unclear.
objectiveWe investigated the active ingredients and mechanism of action of the sour jujube kernel-fiveflavour berry pair in treating insomnia.
methodsThe chemical compositions and targets of sour jujube kernels and five-flavour berries were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, PubChem, and PharmMapper. Insomnia disease targets were screened using the GeneCards, Online Mendelian Inheritance in Man, and Therapeutic Target Database. We constructed shared target data for topological analysis and network construction using the STRING database and the Cytoscape software. Gene Ontology functional and metabolic pathway analyses were performed using the DAVID database and validated through molecular docking using AutoDock and PyMOL software.
resultsThis study demonstrated that the sour jujube kernel and five-flavour berry combination primarily addresses insomnia through the activity of eight hub genes:
conclusionWe establish a theoretical foundation for further experimental studies, which may lead to the application of sour jujube kernel and five-flavour berry in clinical practice.
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Registered trials
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