Evidence map›Paper›PMID 40264321›Full record

ReviewCurrent pharmaceutical design2025

Exploring Hot Melt Extrusion from Process to Product with Methodologies and Drug-Delivery Applications: A Review.

Praveen Halagali, Mahalaxmi Rathnanand, Vamshi Krishna Tippavajhala

Abstract readReview
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In one paragraph

Review in Current pharmaceutical design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Praveen HalagaliDepartment of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.ORCID 0000-0002-1619-8416
Mahalaxmi RathnanandDepartment of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.ORCID 0000-0002-6339-2836
Vamshi Krishna TippavajhalaDepartment of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For the pharmaceutical industry, hot-melt extrusion (HME) has become a cutting-edge production process. Compared to conventional procedures, HME is a solvent-free approach that offers numerous applications, cost-effectiveness, and continuous manufacturing. Studying the formulation and process characteristics should be prioritized in order to satisfy requirements. Many distinct dosage forms for different purposes can be formulated by altering the equipment design and a few processing parameters. For the intended outcome, the HME process must run smoothly and continuously. In this regard, pre-formulation study plays a main role in selecting the carrier, drug, and other required excipients. This review provides a comprehensive understanding of various equipment parts, HME materials and processes, formulation development, and HME in the delivery of drugs. It also highlights the applications and patents of HME.

Indexed as

Drug Delivery SystemsHot Melt Extrusion TechnologyDrug CompoundingHot TemperatureHumansPharmaceutical PreparationsPharmaceutical PreparationsContinuous manufacturingdrug deliveryhot-melt extrusionpolymer matrix.solid dispersiontwin screw extruders

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.