Evidence map›Paper›PMID 40264317›Full record

ArticleCurrent medicinal chemistry2026

Synthesis and Hybridization Properties of RNA Oligomers Containing Biologically Relevant 5-Aminomethyl-2-thiouridines (xnm

Paulina Kuwerska, Karolina Bartosik, Katarzyna Kulik, Agnieszka Dziergowska, Justyna Jakubowska, Barbara Nawrot, Grazyna Leszczynska

Abstract read
PubMed Publisher
In one paragraph

Article in Current medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Mechanistic Insights Into the Oxidative Reactivity of 2-Selenouridine in tRNA.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  2. Chalcogen-modified Nucleic Acid Analogues.Current medicinal chemistry · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Paulina KuwerskaInstitute of Organic Chemistry, Lodz University of Technology, Zeromskiego, 116, 90-924, Lodz, Poland.ORCID 0000-0003-1198-233X
Karolina BartosikInstitute of Organic Chemistry, Lodz University of Technology, Zeromskiego, 116, 90-924, Lodz, Poland.ORCID 0000-0001-8094-6741
Katarzyna KulikCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Department of Bioorganic Chemistry, Sienkiewicz, 112, 90-363, Lodz, Poland.ORCID 0000-0002-7169-181X
Agnieszka DziergowskaInstitute of Organic Chemistry, Lodz University of Technology, Zeromskiego, 116, 90-924, Lodz, Poland.ORCID 0000-0002-8888-380X
Justyna JakubowskaInstitute of Organic Chemistry, Lodz University of Technology, Zeromskiego, 116, 90-924, Lodz, Poland.ORCID 0009-0000-0873-0874
Barbara NawrotCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Department of Bioorganic Chemistry, Sienkiewicz, 112, 90-363, Lodz, Poland.ORCID 0000-0002-4084-4334
Grazyna LeszczynskaInstitute of Organic Chemistry, Lodz University of Technology, Zeromskiego, 116, 90-924, Lodz, Poland.ORCID 0000-0002-6874-022X

Funding

Local Government of the Lodzkie Region 54/OPP/2023
6 · The paper itself

Abstract

introduction2-Thiouridines with C5-aminomethyl substituents (nm

methodsIn this work we investigate the hybridization and structural properties of a representative group of naturally existing xnm5-2-thiouridines by thermodenaturation and circular dichroism studies of xnm

resultsOur results demonstrate the general tendency of xnm5-substituents to decrease the stability of xnm

conclusionOur findings suggest that the biological importance of xnm

Indexed as

RNAThiouridineBase PairingNucleic Acid ConformationNucleic Acid HybridizationRNA, Transfer2-thiouridineRNARNA, TransferThiouridine5-aminomethyl-2-thiouridinesbase pairingmodified nucleosidessugar conformationtRNAzwitterionic form

Identifiers

PMID40264317

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.