Observational studyScandinavian journal of trauma, resuscitation and emergency medicine2025
Early fluid balance and mortality following extracorporeal cardiopulmonary resuscitation: a high volume, single center study.
Observational study in Scandinavian journal of trauma, resuscitation and emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Volume therapy for cardiac arrest: a systematic review and meta-analysis.Resuscitation plus · 2026Article
- Evaluation and analysis of clinical outcome prediction for trauma patients based on machine learning.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026Article
- The association between fluid balance trajectories and prognosis in ICU patients with cardiac arrest, a group-based trajectory model analysis.Frontiers in nutrition · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFor patients supported with venoarterial extracorporeal membrane oxygenation (VA-ECMO), a positive cumulative fluid balance at day three has been associated with increased mortality. However, there is limited evidence examining this association in patients requiring extracorporeal cardiopulmonary resuscitation (ECPR). The aims of this study were to (1) to describe contemporary fluid practice in patients requiring ECPR and (2) assess the relationship between early cumulative fluid balance and 28-day mortality.
methodsThis was a retrospective, single centre, observational study using data collected from the EXCEL registry and the hospital electronic medical record. All patients undergoing ECPR from January 2017 until December 2022 were identified using a prospectively collected database. Patients aged < 18 years old or had extra-corporeal support ceased prior to arrival to the intensive care unit were excluded. Fluid data was collected for days 1,2,3 and 7; and cumulative balances reported for day 3 and day 7.
results104 patients were identified, of which 100 were included. The mean age was 48.9 (SD 14.1) years, 72 (72%) were male. 54 (54%) were out-of-hospital cardiac arrests. Median low flow time was 43 (IQR 39-76) minutes. 51 (51%) had died by day 28. After adjusting for location of cardiac arrest, return of spontaneous circulation and duration of ECMO, a 1 L increase in cumulative fluid balance to the end of day 3 was not independently associated with 28-day mortality (adjusted OR 1.09 [95% CI 0.97-1.22]), however by day 7 this was independently associated with an 11% increased risk of 28-day mortality (adjusted OR 1.11 [95% CI 1.001-1.23]).
conclusionA one litre increase in CFB at the end of day 3 was not associated with 28-day mortality; but a one litre increase in CFB by the end of day 7 was associated with an 11% increase in the odds of day 28 mortality. The impact of restrictive fluid management strategies in those requiring ECPR should be assessed in prospective trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.