ArticleBreast cancer research : BCR2025
Breast cancer-specific survival by molecular subtype in different age groups of women in Scotland.
Article in Breast cancer research : BCR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Ten-year survival of women with invasive breast cancer by stage, molecular subtype, and grade combined: a population-based study.The oncologist · 2026Article
- Machine learning for the prediction of three-year survival in locally advanced breast cancer patients receiving neoadjuvant chemotherapy using quantitative ultrasound imaging.Scientific reports · 2026Article
- Breast cancer survival and mortality among women with type 2 diabetes: a retrospective cohort study.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundAge and molecular subtypes are important prognostic factors in breast cancer (BC). Here, we explore how age and molecular subtypes influence BC survival in Scotland.
methodsWe analysed data from 71,784 women diagnosed with invasive BC in Scotland between 1997 and 2016, with follow-up until 31st December 2018 (median follow-up time = 5.5 years). Cox models estimated Hazard Ratios (HR) for BC-specific death by age group (with women of screening age, 50-69 years old, as the reference) within each molecular subtype, adjusting for prognostic factors. The cumulative incidence function was plotted to account for competing risks.
resultsDuring the study period, 37% of women died, with 53% of deaths attributed to BC. Women aged 70 + years had increased BC-specific death compared to women aged 50 to 69 years with the same subtype. HRs (95% CI) were 1.49 (1.23-1.80) for luminal A, 1.39 (1.14 to 1.69) for luminal B tumours and 1.49 (1.15 to 1.94) for triple negative breast cancer (TNBC). Women aged < 50 years had lower risk of BC death in luminal A subtype only, with HR of 0.66 (0.51-0.86) compared to women aged 50 to 69 years. Competing risks analysis showed higher cumulative incidence of death from non-BC causes, particularly for women aged 70 + years with hormone positive subtypes. Stage, treatment, and molecular subtype were the strongest prognostic factors for BC-specific mortality across all ages.
conclusionsAge influences BC-specific mortality particularly within luminal subtypes. In contrast, other tumour characteristics and treatment are key prognostic factors for non-luminal subtypes. Future studies should investigate other markers of BC mortality particularly among over 70-year-olds, who account for 60% of BC deaths in the UK.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.