SynthesisBMC oral health2025
Does platelet-rich fibrin enhance the outcomes of peri-implant soft tissues? A systematic review.
Synthesis in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07667855 (Peri-implant Soft Tissue Augmentation Using Microneedling With i-PRF vs. Connective Tissue Graft), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Peri-implant Soft Tissue Augmentation Using Microneedling With i-PRF vs. Connective Tissue Graft: A Randomized Controlled Clinical Trial
Who cites it
13 citing papers in PubMed.
- Comparative efficacy of fascia lata allograft, platelet-rich fibrin, and connective tissue graft for peri-implant soft tissue augmentation: a randomized controlled clinical trial.BMC oral health · 2026Trial
- Platelet-rich fibrin versus acellular dermal matrix for vertical soft tissue augmentation simultaneously with dental implantation: a 3-month randomized pilot clinical trial.BMC oral health · 2025Trial
- Platelet-derived concentrates in the immunological management of periodontitis: from dysbiosis to personalized approaches.Odontology · 2026Review
- The Role of Biologically Active Materials in Peri-Implant Diseases.Journal of clinical medicine · 2026Review
- Utilization of platelet rich fibrin in soft tissue augmentation around dental implant: a systematic review and meta-analysis.Odontology · 2026Review
- Clinical effectiveness of albumin-enriched platelet-rich fibrin (Alb-PRF) in periodontal and peri-implant regenerative surgery: a systematic review.Odontology · 2026Review
- Horizontal Platelet-Rich Fibrin Membrane Block for Peri-Implant Soft Tissue Augmentation: An Experimental Animal Study with Clinical Illustration.Dentistry journal · 2026Article
- Short-Term Bone Healing in Anterior Maxillary Sockets Using L-PRF With or Without Synthetic HA/β-TCP: A Randomized Clinical Trial.Journal of functional biomaterials · 2025Article
- Effect of Leukocyte- and Platelet-Rich Fibrin on Peri-Implant Mucosal Thickness in Edentulous Patients Treated with Mandibular Implant-Retained Overdentures: A Randomized Controlled Trial.Journal of clinical medicine · 2025Article
- Periodontal Phenotype Thickening Using Sticky Bone and Platelet-Rich Fibrin: A Case Report.Cureus · 2025Article
- Diagnostic and Clinical Outcomes of Three Regenerative Strategies for Alveolar Bone Defects: A Comparative Study Using CBCT and ISQ.Diagnostics (Basel, Switzerland) · 2025Article
- The effect of liquid platelet-rich fibrin on oral cells and tissue engineered oral mucosa models in vitro.Scientific reports · 2025Article
- Evaluation of soft and hard tissue responses to dental implants placed with and without platelet-rich fibrin.Bioinformation · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImproving soft tissue quality and quantity around dental implants is crucial for successful outcomes. Platelet-Rich Fibrin (PRF) is showing promise in enhancing wound healing and implant stability. This systematic review aims to evaluate the clinical benefits of PRF in soft tissue regeneration around dental implants compared to standard methods.
methodsThis systematic review adhered to the PRISMA guidelines and utilizing the PICO methodology, investigated the use of Platelet-Rich Fibrin (PRF) in soft tissue augmentation during implant therapy. The primary outcomes assessed include the width of keratinized mucosa and soft tissue thickness, comparing PRF interventions to standard techniques.The study included randomized controlled trials (RCTs) and comparative studies, focusing on human patients needing implant therapy with or without PRF. An extensive search of databases and manual references was conducted; data extraction involved assessing study quality and risk of bias, but due to high heterogeneity among studies, a meta-analysis was not feasible, leading to a systematic review of the available literature.
resultsA total of 766 references were initially identified, with 29 being eligible after screening. Nine studies were included for detailed review. The findings revealed that PRF is effective in increasing the width of keratinized mucosa (KT) and soft tissue thickness (STT) around implants. Even if free gingival grafts (FGG) sometimes performed better. However, the differences between PRF and FGG were not clinically significant, and PRF offers lower cost, ease of use, and reduced morbidity. There was limited information on the esthetic outcomes of PRF, with only two studies addressing this aspect, showing mixed results.
conclusionOverall, PRF demonstrated positive effects on KT width and STT, but further research with rigorous methodology and larger sample sizes is needed to better understand its impact on implants health and esthetics.
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