Evidence map›Paper›PMID 40264056›Full record

ArticleBMC psychiatry2025

Thinning of the temporal and insular cortex is associated with negative symptoms and impaired attention in Chinese chronic schizophrenia patients with deficit syndrome.

Jin Li, Xiaobin Zhang, Junjie Wang, Haidong Yang, Man Yang, Ju Gao, Xiangdong Du

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In one paragraph

Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jin Li *Institute of Mental Health, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, 11 Guangqian Road, Suzhou, 215137, Jiangsu, China.
Xiaobin Zhang *Institute of Mental Health, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, 11 Guangqian Road, Suzhou, 215137, Jiangsu, China.
Junjie WangInstitute of Mental Health, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, 11 Guangqian Road, Suzhou, 215137, Jiangsu, China.
Haidong YangDepartment of Psychiatry, The Fourth People's Hospital of Lianyungang, The Affiliated KangDa College of Nanjing Medical University, Lianyungang, 222003, P. R. China.
Man YangDepartment of Psychiatry, The Fourth People's Hospital of Lianyungang, The Affiliated KangDa College of Nanjing Medical University, Lianyungang, 222003, P. R. China.
Ju GaoInstitute of Mental Health, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, 11 Guangqian Road, Suzhou, 215137, Jiangsu, China.
Xiangdong DuInstitute of Mental Health, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, 11 Guangqian Road, Suzhou, 215137, Jiangsu, China. xiangdong-du@163.com.

Funding

Suzhou Clinical Key Disciplines for Geriatric Psychiatry SZXK202116Suzhou Clinical Medical Center for mood disorders No.Szlcyxzx202109 to X.B.Z.Suzhou Key Technologies Program SKY2021063Suzhou Municipal Science and Technology Bureau SKJY2021142
6 · The paper itself

Abstract

backgroundThe considerable clinical heterogeneity of schizophrenia poses significant challenges for elucidating its neurobiology. The concept of deficit schizophrenia (DS) is a valuable framework for addressing the heterogeneity of schizophrenia. Growing evidence suggests notable differences between deficit (DS) and nondeficit (NDS) schizophrenia, indicating that DS could represent a separate disease entity.

methodsWe aimed to use FreeSurfer to identify specific changes in cortical thickness among NDS patients and healthy controls (HCs) in a Chinese sample. Furthermore, we examined the potential relationships between changes in cerebral cortical thickness and negative symptoms and attention deficits in DS patients. A total of 142 subjects (48 HCs, 50 NDSs, and 44 DSs) underwent MRI scans and completed the assessment of psychopathological severity and cognitive performance.

resultsCompared with HCs, DS and NDS patients presented common cortical thinning in the right insula, whereas cortical thinning in the left supramarginal cortex was more prominent in DS patients. We also found that thinning of the temporal and insular cortex was correlated with negative symptoms and impaired attention in DS patients.

conclusionsCortical thinning in specific brain regions in DS patients was found to be correlated with specific clinical and cognitive symptoms.

Indexed as

Cerebral CortexCerebral Cortical ThinningInsular CortexSchizophreniaTemporal LobeAdultAttentionCase-Control StudiesChinaChronic DiseaseFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedSchizophrenic PsychologyBrain cortical thicknessDeficit schizophreniaNegative symptomsNeuropsychological assessmentNondeficient schizophrenia

Identifiers

PMID40264056
PMCPMC12016080

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.