ArticleBMC public health2025
Associations of exposure to volatile organic compounds with biological aging: a cross-sectional study.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Biological age acceleration predicts mortality and heart failure after acute myocardial infarction in older adults.Journal of geriatric cardiology : JGC · 2026Article
- Dietary Factors Drive Volatile Organic Compound Exposure and Modulate Its Impact on Multi-Dimensional Biological Aging.Food science & nutrition · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVolatile organic compounds (VOCs) are recognized as potentially linked to various health damages. However, the effects of VOCs exposure on biological aging remain unknown. This study aimed to investigate this potential association through cross-sectional analyses.
methodsThis study analyzed data from the National Health and Nutrition Examination Surveys (2011-2016). There was a total of 29,902 participants and 3,205 participants were finally included. Biological aging was represented by PhenoAge acceleration calculated through multiple indicators including albumin and alkaline phosphatase and so on. We employed weighted multivariate logistic regression to examine the correlation between individual VOC exposure and biological aging. The least absolute shrinkage and selection operator regression was utilized to identify key VOCs for the weighted quantile sum (WQS) regression, which assessed the association between mixed exposure to VOCs and biological aging. In addition, subgroup analyses were conducted using data from the same database on individuals' daily behaviors, such as physical activity levels, smoking, and alcohol consumption, to explore the influence of daily behaviors on the above associations.
resultsLogistic regression analysis indicated that exposure to various individual VOCs was associated with biological aging. The WQS results revealed a significant positive association between mixed exposure to VOCs and biological aging (P < 0.001, OR = 1.523). Additionally, we found that participants with drinking, smoking, and lower levels of physical activity were more affected by exposure to individual VOCs. Mixed VOCs exposures differed only between smoking (P < 0.001, OR = 1.422) and non-smoking populations (P = 0.216, OR = 1.158).
conclusionVOCs exposure was associated with biological aging, and daily behaviors may influence an individual's susceptibility to such exposure. This discovery provided a new way of thinking about slowing down the aging process and improving overall health.
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