ArticleBMC ophthalmology2025
Analysis of retinal microstructure and electrophysiology in eyes following pars plana vitrectomy and membrane peeling for vitreomacular interface disorders.
Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Correlation of retinal imaging with presence of inner limiting membrane pores in idiopathic epiretinal gliosis.International journal of retina and vitreous · 2026Article
- Detection of Occult Retinal Breaks Using Subretinal Dye in Recurrent Retinal Detachment Surgery.Turkish journal of ophthalmology · 2026Observational
- Clinical characteristics and surgical outcomes of full-thickness macular hole secondary to retinal vein occlusion.BMC ophthalmology · 2026Article
- Epiretinal membrane peeling in eyes with pseudophakia: prognostic and morphological factors of visual outcomes.BMC ophthalmology · 2025Article
- Current Topics in OCT Applications in Vitreoretinal Surgery.Bioengineering (Basel, Switzerland) · 2025Review
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5 authors.
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Abstract
purposeTo investigate the relationship between retinal structural biomarkers using spectral-domain optical coherence tomography (SD-OCT) and macular function before and after surgery.
methodsForty-four eyes of 44 patients were included. Ophthalmological examinations included visual acuity (VA), intraocular pressure, OCT angiography (OCTA), and multi-focal electroretinography (mf-ERG) at baseline (pre-surgery) and post-operative follow-up. The ILM texture during peeling was graded by the surgeon as follows: Grade 1, fragile; Grade 2, easy to peel in a sheet; and Grade 3, sticky. The cross-sectional area of the ganglion cell layer and central retinal thickness in the fovea were evaluated using ImageJ software of SD-OCT. The presence of a dissociated optic nerve fiber layer (DONFL) was evaluated using en face OCTA images. mf-ERG results are shown as the ratio between the average amplitudes from rings 1 and 2 (central) and rings 4 and 5 (peripheral): the P1 ratio.
resultsBased on the SD-OCT morphological characteristics of the foveal area, 14 cases were classified into ERM group 1 (mainly outer retinal thickening or more tenting of the outer retina), 11 into ERM group 2 (prominent inner retinal thickening), 9 into ERM group 3 (ERM with macular hole), and 10 into ERM group 4 (full thickness macular hole without ERM and vitreomacular traction without ERM). Morphological characteristics were correlated with ILM texture (p = 0.0031) and DONFL (p < 0.0001). Group 2 and group 3 ERM had a stickier ILM when peeling and showed DONFL in 100% of the cases. Group 1 ERM had a more fragile ILM when peeling and did not result in DONFL. ILM texture was also correlated with DONFL (p < 0.0001), in which sticky ILM resulted in DONFL after the operation. Eyes with DONFL showed a greater decrease in ganglion cell complex/central retinal thickness in the foveal area, slow P1 ratio recovery, and slower VA improvement.
conclusionsERM with prominent inner retinal structural changes are likely to have a stickier ILM when peeled, leading to a subsequently DONFL. The appearance of DONFL results in an initial decrease in macular function recovery and slower post-operative visual improvement. Surgeons should be more delicate when peeling sticky ILM, especially in eyes with ERM with prominent inner retinal thickening or macular holes.
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