ArticleBMC cancer2025
Dual-Time-Point
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
backgroundFixed focal fluorine 18 fluorodeoxyglucose (
methodsA retrospective analysis was conducted on patients who underwent dual-time-point
resultsA total of 122 patients were enrolled in this study. A total of 141 lesions was studied, 80 (56.7%) of which were diagnosed as colorectal carcinoma or advanced adenoma. When compared with non-advanced lesions, colorectal carcinoma/advanced adenoma had higher SUVmax in delayed scan (25.1 ± 14.2 vs. 14.5 ± 7.5, P<0.001), and higher RI (32.9%±25.4% vs. 7.8%±28.4%, P<0.001) in dual-time-point PET/CT. SUVmax in delayed scan (odds ratio [OR],1.084; 95% confidence interval [CI]: 1.037, 1.134; P<0.001) and RI (OR, 20.120; 95% CI: 4.068, 99.516; P<0.001) were identified as independent predictors for colorectal carcinoma/advanced adenoma by multivariable logistic regression analysis. When combining the SUVmax in the delayed scan with the retention index, the area under the receiver operating characteristic (ROC) curve achieved 0.801, and the sensitivity and specificity for predicting colorectal carcinoma/advanced adenoma were found to be 65.0% and 80.3%, respectively. Based on the threshold values of SUVmax in the delayed scan and RI, we observed prediction rates of 13.9% (5 out of 36), 58.6% (34 out of 58), and 87.2% (41 out of 47) for colorectal carcinoma/advanced adenoma in the low-, moderate-, and high-risk subgroups, respectively.
conclusionsDual-time-point PET/CT aids in distinguishing between colorectal cancer/advanced adenoma and non-advanced lesions in fixed focal FDG uptake. Higher SUVmax in delayed scan and higher RI are predictive factors for colorectal carcinoma/advanced adenoma.
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