ArticleBMC geriatrics2025
Effect of small airway dysfunction on large airway function parameters in elderly adults.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTo investigate the effect of simple small airway dysfunction (SAD) on large airway function parameters in old people.
methodsElderly patients aged 60-80 years with complete pulmonary function data including the measured/predicted values of ≥ 80% for each of forced expiratory capacity (FVC), forced expiratory volume in one second (FEV1), and peak expiratory flow (PEF), and FEV1/FVC ≥ 70% were included. Patients with no known smoking history, normal chest computerized tomography, and the measured/predicted values of ≥ 70% for each of maximal flows at 50% and 25% of remaining FVC (MEF50 and MEF25) and maximum mid-expiratory flow (MMEF) were categorized into the control group, whereas patients with the measured/predicted values of < 65% for more than 2 of MEF50, MEF25, and MMEF were divided into the observation group. 104 patients with simple SAD (observation group) and 102 patients with normal pulmonary function (control group) were selected.
resultsThe parameters of small airway function including MEF50, MEF25, and MMEF were positively correlated with slow vital capacity (SVC), FVC, FEV
conclusionsSimple SAD was associated with large airway pulmonary function, and PEF may not be a suitable parameter for large airway pulmonary function in the old adults. SVC-FVC > 0.02 L had a certain predictive value for SAD in the elderly.
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