Evidence map›Paper›PMID 40263998›Full record

ArticleBMC gastroenterology2025

Translation and validation of the Swedish version of the EORTC LMC-21, the disease-specific questionnaire for assessing health-related quality of life in patients with colorectal liver metastases.

Anna Lindhoff Larsson, Peter Holka, Bengt Isaksson, Oskar Hemmingsson, Per Sandström, Bergthór Björnsson

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Anna Lindhoff LarssonDepartment of Surgery in Linköping, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden. anna.lindhoff.larsson@liu.se.
Peter HolkaDepartment of Surgery, Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund, Sweden.
Bengt IsakssonDepartment of Surgical Sciences, Sweden Department of Surgery, Uppsala University, Akademiska Hospital, Uppsala, Sweden.
Oskar HemmingssonDepartment of Surgical and Perioperative Sciences, Surgery, Umeå University, Umea, Sweden.
Per SandströmDepartment of Surgery in Linköping, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Bergthór BjörnssonDepartment of Surgery in Linköping, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to translate the health-related quality-of-life questionnaire EORTC QLQ-LMC21 into Swedish and to test its clinical and psychometric reliability and validity in patients with liver metastases from colorectal cancer (CRC) undergoing surgical treatment.

methodsThe Swedish versions of the EORTC QLQ-C30 and EORTC QLQ-LMC21 were administered to 250 patients with liver metastases from CRC in four Swedish hospitals before and 3 months after surgical treatment. Psychometric validation of the questionnaire´s structure, reliability, and convergent and divergent validity was performed.

resultsData from 242 (97%) patients were suitable for analysis. The QLQ-LMC21 was found to be sensitive to changes over time. Cronbach´s alpha coefficient indicated good internal consistency, ranging from 0.84 to 0.89. Test-retest reliability was evaluated in 120 patients (49%), and the intraclass correlation coefficient (ICC) indicated good reproducibility, ranging from 0.67 to 0.93. Convergent and discriminant validity were demonstrated adequately in the multitrait scaling analysis. There were weak correlations between the QLQ-C30 and QLQ-LMC21, which confirms that the health problems addressed by the QLQ-LMC21 are different from those addressed by the QLQ-C30.

conclusionsThe Swedish version of the EORTC QLQ-LMC21 proved to be a valid and reliable questionnaire to use in conjunction with the EORTC QLQ-C30.

Indexed as

Colorectal NeoplasmsLiver NeoplasmsQuality of LifeAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedPsychometricsReproducibility of ResultsSurveys and QuestionnairesSwedenTranslationsColorectal cancerEORTC QLQ-LMC21Psychometric validationQuality of life (QoL)

Identifiers

PMID40263998
PMCPMC12013156

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.