ArticleBMC cardiovascular disorders2025
Blood transfusion in percutaneous left atrial appendage occlusion: a nationwide analysis of incidence, predictors, and outcomes.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Aspiration pneumonia in diabetic ketoacidosis: a decade-long analysis of occurrence , associated risk factors and clinical outcomes in 530,700 US hospitalizations.Diabetology & metabolic syndrome · 2025Article
- Predictors, trends and outcomes associated with urinary tract infections in intracerebral hemorrhage: insights from a National Inpatient Sample Study (2010-2022).European journal of medical research · 2025Article
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with atrial fibrillation (AF) may benefit from PLAAO, a method proven to reduce the risk of stroke. However, the risk of requiring blood transfusion during the perioperative period has not been adequately evaluated.
objectivesUsing a comprehensive nationwide database, this study aimed to evaluate the frequency of transfusion events, identify contributing factors, and assess clinical outcomes in individuals who underwent PLAAO.
methodsA retrospective evaluation of 61,445 PLAAO procedures, documented in the Nationwide Inpatient Sample database from 2015 to 2019, was conducted. The analysis compared patient characteristics, underlying conditions, medical complications, institutional features, and clinical results between groups requiring and not requiring transfusion support. A multivariable logistic regression model was used to identify key predictors of blood transfusion.
resultsTransfusion support was necessary in 1.8% of procedures (1,090/61,445), with a decrease from 5.0% in 2015 to 1.7% by 2019. Independent factors associated with an increased need for transfusion included female sex, pre-existing conditions (chronic blood loss anemia, coagulopathy, fluid and electrolyte disorders, metastatic cancer, other neurological disorders, and peripheral vascular disorders), and complications (hemorrhage/seroma/hematoma, postoperative shock, urinary tract infections, gastrointestinal bleeding, acute heart failure, dialysis). Protective factors included elective admission and hospital location in the Midwest/North central, South, or West regions. The transfusion group experienced significantly poorer outcomes, with higher mortality (3.2% vs. 0.1%, P < 0.05), longer hospitalizations (median 3 vs. 1 day, P < 0.05), and greater hospital expenses (median $159,635 vs. $101,953, P < 0.05).
conclusionPatients undergoing PLAAO who require blood transfusion face significantly higher risks of death, extended hospital stays, and increased healthcare expenses. A thorough pre-procedure risk assessment could improve patient selection and minimize transfusion requirements.
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