ArticleThe world journal of men's health2026
Global Andrology Forum (GAF) Clinical Guidelines on the Management of Infertile Men with Varicocele.
Article in The world journal of men's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- The role of the mitochondrial injury-mediated oxidative stress-sterile inflammation axis in varicocele-induced infertility: a narrative review.Basic and clinical andrology · 2026Review
- Clinical Recommendations for the Management of Male Infertility: A Consensus from the Korean Society for Sexual Medicine and Andrology (KSSMA) Clinical Practice Guideline Committee.The world journal of men's health · 2026Review
- Re-Imagining Male Infertility Guidelines through the Global Andrology Forum.The world journal of men's health · 2026Article
- Is Varicocele Truly Unilateral? Contralateral Involvement and Bilateral Testicular Effects in Male Infertility: A Narrative Review.Journal of personalized medicine · 2026Review
- Why Varicoceles Recur: Missed Venous Anatomy and Contemporary Strategies for Salvage.Journal of clinical medicine · 2026Review
- Scrotal Pain Alters Doppler Findings in Varicocele: A Prospective Evaluation.Journal of clinical medicine · 2026Article
- Global Andrology Forum Clinical Practice Guidelines: Because Male Reproductive Health Matters! Introducing a Novel Approach to Address Common Yet Controversial Aspects of Male Infertility.The world journal of men's health · 2026Article
- Male Reproductive Phenotype Heterogeneity in Varicocele: A Hypothesis-Generating Threshold-Resilience Framework and Research Agenda.Reproductive medicine and biologyReview
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Authors and funding
48 authors.
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Abstract
purposeVaricocele is among the most common reversible causes of male infertility. Although varicocele is prevalent and there is a growing body of literature on the subject, there are still numerous debates surrounding the matter. This study presents Global Andrology Forum (GAF) clinical guidelines on the management of infertile men with varicocele. MATERIALS AND
methodsA team of clinicians and reproductive experts reviewed contemporary evidence on all aspects of varicocele, including systematic reviews, meta-analyses, and the results of the GAF global survey of practices. They then formulated expert statements and recommendations, subject to a modified Delphi process until a consensus was reached. The final statements and recommendations were rated using the GRADE system.
resultsA total of 31 statements and recommendations on the evaluation and management of varicocele were introduced and scored by 24 experts. All experts agreed with the final statements. Varicocele is a significant contributor to male infertility. Its diagnosis is based mainly on physical examination, although imaging can be used in certain cases. Clinical varicocele associated with abnormal sperm parameters is the primary unanimous indication of varicocele repair. However, other indications can still be considered, and recommendations for a tailored approach to controversial situations have been presented. There is inadequate evidence on the use of medical therapy for varicocele.
conclusionsThese clinical guidelines on the management of infertile men with varicocele, based on the GAF surveys, systematic reviews, and meta-analyses, point out the pivotal importance of varicocele in modern Andrology. Continued research is crucial to improving diagnostic accuracy and treatment outcomes, ultimately enhancing reproductive health for men with varicocele. Therefore, the current guidelines allow clinicians to develop effective management strategies for a common issue and address practical questions where evidence is lacking.
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