SynthesisJournal of medical virology2025
Perinatal Enterovirus Infection in Neonates: A Systematic Review.
Synthesis in Journal of medical virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Invasive Neonatal Enterovirus Infection: A Case Series and Review of the Literature.Children (Basel, Switzerland) · 2026Article
- Enterovirus infections in children.Pediatric investigation · 2026Review
- Sulodexide protects against sepsis-induced liver injury in neonatal rat by attenuating oxidative stress, apoptosis, and NF-κB/MAPK signaling.Molecular biology reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enteroviruses (EVs) are a common cause of neonatal infections, and perinatal EV infection can lead to severe neonatal disease, including sepsis-like presentations, and adverse pregnancy outcomes. However, a comprehensive understanding of the prevalence and clinical manifestations of perinatal EV infection is lacking. This systematic review investigated the prevalence and clinical manifestations of perinatal EV infection. A comprehensive literature search was performed in PubMed, Embase, and KoreaMed up to August 26, 2024. Studies describing perinatal outcomes related to EV infection in neonates and pregnant women were included. Data extraction and quality assessment were performed independently by two reviewers. Nine studies (three each from America, Europe, and Asia) were included. Severe neonatal complications included sepsis-like disease and death. Maternal symptoms included fever, uterine contractions, and rash. Perinatal EV infection prevalence ranged from 60% to 77.8% in severely affected neonates, 25% to 57.1% in infected pregnant women, and 4.6% to 46.1% in all infected newborns. Placental infection was confirmed in 38.3% of severe neonatal cases. This review highlights the global presence and potential severity of perinatal EV infections, underscoring the need for enhanced surveillance, standardized diagnostic protocols, and further research to inform effective prevention and management strategies.
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Registered trials
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