Evidence map›Paper›PMID 40263920›Full record

ArticleJournal of medical virology2025

Prolonged Zika Virus NS1 Protein Circulation in Patient Sera Impacts Clinical Outcome Before the Rise of a Specific IgM Response.

Carole Tamietti, Tharshana Stephen, Alexander Rouvinski, Bernard Tenebray, Isabelle Leparc-Goffard, Franck de Laval, Sandrine Fernandes-Pellerin, Jean-Claude Manuguerra, Félix Rey, Milena Hasan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Carole TamiettiInstitut Pasteur, Université Paris Cité, Unité de Virologie Structurale, Paris, France.
Tharshana StephenInstitut Pasteur, Université Paris Cité, Single Cell Biomarkers UTechS, Paris, France.
Alexander RouvinskiInstitut Pasteur, Université Paris Cité, Unité de Virologie Structurale, Paris, France.
Bernard TenebrayUnité de virologie, Institut de Recherche Biomédicale des Armées, Marseille, France.
Isabelle Leparc-GoffardUnité de virologie, Institut de Recherche Biomédicale des Armées, Marseille, France.
Franck de LavalService de Santé des Armées, CESPA, Centre d'épidémiologie et de santé publique des armées, Marseille, France.
Sandrine Fernandes-PellerinInstitut Pasteur, Université Paris Cité, Clinical Research Coordination Office, Paris, France.
Jean-Claude ManuguerraInstitut Pasteur, Université Paris Cité, Laboratory for Urgent Response to Biological Threats (CIBU), Environment and Infectious Risks (ERI) Unit, Paris, France.
Félix ReyInstitut Pasteur, Université Paris Cité, Unité de Virologie Structurale, Paris, France.
Milena HasanInstitut Pasteur, Université Paris Cité, Single Cell Biomarkers UTechS, Paris, France.
Cyril BadautUnité des Virus Emergents (UVE: Aix-Marseille Univ, Université di Corsica, IRD 190, Inserm 1207, IRBA), France.
Marie FlamandInstitut Pasteur, Université Paris Cité, Unité de Virologie Structurale, Paris, France.
Séverine MatheusInstitut Pasteur, Université Paris Cité, Laboratory for Urgent Response to Biological Threats (CIBU), Environment and Infectious Risks (ERI) Unit, Paris, France.
Sébastien BriolantDépartement Microbiologie et maladies infectieuses, Institut de Recherche Biomédicale des Armées (IRBA), Unité Parasitologie et Entomologie, Marseille, France.ORCID 0000-0001-8872-1774

Funding

This research was supported by a global alliance for Zika virus control and prevention (ZIKAlliance) (734548).
6 · The paper itself

Abstract

Zika virus (ZIKV) is a neurotropic virus that can be transmitted congenitally. In ZIKV-infected pregnant women, placental dysfunction is associated with the secretion of nonstructural protein 1 (NS1). In this study, the kinetics of NS1 secretion and antibody response were assessed and characterized in the serum of ZIKV-positive adult patients recruited in French Guiana. NS1 concentrations were quantified by a single molecule array (SiMoA) in 164 sequential serum samples collected from thirty patients during the first month after onset of symptoms. Serum NS1 concentrations in this cohort were unexpectedly low and ranged from 0.1 pg/mL to 380 pg/mL. The median persistence of NS1 in patients with a clinical score of 2 (6 days) was significantly lower than in patients with a clinical score of 3 (8 days). In both groups of patients, anti-NS1 IgM and IgG kinetics were similar but patients with a milder clinical score of 2 had statistically higher levels of specific IgM than those with a clinical score of 3. Herein, it was shown that NS1 circulating in patient sera is associated with clinical outcome, emphasizing the role of NS1 in ZIKV pathogenesis.

Indexed as

Antibodies, ViralImmunoglobulin MViral Nonstructural ProteinsZika VirusZika Virus InfectionAdultFemaleHumansImmunoglobulin GMaleMiddle AgedPregnancyYoung AdultAntibodies, ViralImmunoglobulin GImmunoglobulin MNS1 protein, zika virusViral Nonstructural ProteinsarbovirusIgMNS1SiMoAZika virus

Identifiers

PMID40263920
PMCPMC12015152

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.