ArticleNature immunology2025
Endothelial dysfunction drives atherosclerotic plaque macrophage-dependent abdominal aortic aneurysm formation.
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Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
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Who cites it
30 citing papers in PubMed.
- Systolic blood pressure variability as a risk factor for abdominal aortic aneurysm: a prospective cohort study with genomic and proteomic profiling.European journal of epidemiology · 2026Article
- Modeling the Exposome in Murine Cardiovascular Disease.JACC. Basic to translational science · 2026Review
- Development of endothelial injury under chemical hypoxia: early migration impairment precedes cytotoxicity in CoClMolecular biology reports · 2026Article
- Review
- Carotid plaque macrophage burden and inflammatory lipid-associated macrophage markers predict secondary major adverse cardiovascular events after endarterectomy.European heart journal · 2026Article
- Urinary 11-dehydrothromboxane B2 as a dynamic biomarker of atherosclerotic thrombotic risk and its association with plaque instability.Thrombosis journal · 2026Article
- ERG preserves endothelial identity to limit atherosclerosis.Nature communications · 2026Article
- Single-cell and spatial analyses reveal endothelial-macrophage inflammatory crosstalk in dry age-related macular degeneration.Journal of translational medicine · 2026Article
- CIITA/PRMT5 promote CD4BMC medicine · 2026Article
- A Single-Cell Analysis Reveals Macrophage Heterogeneity Driving Plaque Vulnerability in Coronary and Carotid Arteries.Journal of atherosclerosis and thrombosis · 2026Article
- [Dual role and therapeutic potential of TREM2 in atherosclerosis].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Review
- MMP-Activated Liposomal Nanoplatform Co-loaded with Kaempferol and ICG for Targeted Imaging and Therapy of Abdominal Aortic Aneurysm.ACS applied materials & interfaces · 2026Article
- Lack of endothelial estrogen receptor alpha signaling exacerbates abdominal aortic aneurysm in male mice.American journal of physiology. Heart and circulatory physiology · 2026Article
- Mortality trends and disparities associated with aortic aneurysm and aortic dissection in the United States from 1999 to 2023: a CDC WONDER database analysis.BMC cardiovascular disorders · 2026Article
- Programmable Pentamolecular Cross-Scale Imaging Reveals the Multiplicative Synergistic Effect of High-Fat / High-Salt Diet on Atherosclerosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- COPD airway epithelial cells-derived extracellular vesicles contribute to endothelial dysfunction and atherosclerosis via the miR-141-3p/PDCD4 axis.Journal of nanobiotechnology · 2026Article
- Emerging Mechanisms of Abdominal Aortic Aneurysm.Current atherosclerosis reports · 2026Review
- When Smell Drives Swell: Olfr2 Fuels Inflammation in AAA.Circulation research · 2026Article
- Role of Extracellular Vesicles in Abdominal Aortic Aneurysm: Pathophysiology, Biomarkers, and Therapeutic Potentials.International journal of molecular sciences · 2026Review
- Harnessing the microbiome to regulate myeloid TREM2 expression and innate immune responses.ImmunoHorizons · 2026Article
Corrections and comments
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Authors and funding
51 authors.
Danya Thayaparan *McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada.
Takuo Emoto *Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada. emotot@med.kobe-u.ac.jp.ORCID http://orcid.org/0000-0001-7425-4087
Aniqa B Khan *Department of Immunology, University of Toronto, Toronto, Ontario, Canada. aniqab.khan@mail.utoronto.ca.ORCID http://orcid.org/0000-0003-4627-4536
Rickvinder Besla *Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Homaira HamidzadaDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-0151-9608
Mahmoud El-MakliziToronto General Research Institute, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-1229-5198
Tharini SivasubramaniyamToronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
Shabana VohraToronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
Ash HagermanDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.
Sara NejatToronto General Research Institute, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-2374-5430
Charlotte E Needham-RobbinsToronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
Tao WangToronto General Research Institute, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-6348-2794
Moritz LindquistDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Steven R BottsInstitute of Medical Science, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-2420-4679
Stephanie A SchroerToronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
Masayuki TaniguchiDivision of Pharmacology, Kobe University Graduate School of Medicine, Kobe, Japan.
Taishi InoueDepartment of Cardiovascular Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Katsuhiro YamanakaDepartment of Cardiovascular Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Haotian CuiPeter Munk Cardiac Centre, Toronto, Ontario, Canada.
Edouard Al-ChamiDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.
Hangjun ZhangDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-8950-5141
Marwan G AlthagafiToronto General Research Institute, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-7064-3306
Aja MichalskiToronto General Research Institute, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0009-0008-2788-7648
Joshua J C McGrathMcMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada.
Steven P CassMcMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0002-7032-6239
David LuongToronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
Yuya SuzukiDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.ORCID http://orcid.org/0000-0002-6790-0914
Angela LiDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.
Amina AbowDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Rachel HeoMcMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada.
Shaun PachecoToronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
Emily ChenToronto General Research Institute, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0009-0004-0662-9560
Felix ChiuToronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
John ByrnePeter Munk Cardiac Centre, Toronto, Ontario, Canada.
Tomoyuki FuruyashikiDivision of Pharmacology, Kobe University Graduate School of Medicine, Kobe, Japan.
Mansoor HusainToronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
Peter LibbyDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Kenji OkadaDepartment of Cardiovascular Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Kathryn L HoweToronto General Research Institute, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-6519-2280
Scott P HeximerDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-5489-9240
Tomoya YamashitaDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.ORCID http://orcid.org/0000-0003-0267-3842
Bo WangPeter Munk Cardiac Centre, Toronto, Ontario, Canada.
Barry B RubinPeter Munk Cardiac Centre, Toronto, Ontario, Canada.
Myron I CybulskyToronto General Research Institute, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-1696-2867
Joy RoyDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Jesse W WilliamsCenter for Immunology, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0003-3815-0891
Sarah Q CromeToronto General Research Institute, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-5117-7453
Slava EpelmanToronto General Research Institute, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-3400-4475
Ken-Ichi HirataDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Martin R StampfliMcMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0003-4918-5889
Clinton S RobbinsToronto General Research Institute, University Health Network, Toronto, Ontario, Canada. clint.robbins@utoronto.ca.ORCID http://orcid.org/0000-0001-9848-1495
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently there is no effective pharmacotherapy to prevent the growth and rupture of abdominal aortic aneurysms. Using a mouse model that combines cigarette smoke exposure and hypercholesterolemia, we demonstrated that cigarette smoke exacerbated atherosclerosis, leading to elastin fragmentation, aneurysm formation, rupture and death. Arterial injury was driven by macrophages that accumulated within atherosclerotic plaques and exhibited tissue-degrading proteolytic activity in vivo (a process dependent on the endothelial cell-derived macrophage growth factor CSF-1). Single-nucleus RNA sequencing revealed that cigarette smoke-induced endothelial cell dysfunction promoted monocyte recruitment and inflammatory signaling and amplified vascular injury. Furthermore, single-cell transcriptomic analysis identified conserved macrophage responses across mouse and human abdominal aortic aneurysm, including TREM2
Indexed as
Aortic Aneurysm, AbdominalEndothelial CellsEndothelium, VascularMacrophagesPlaque, AtheroscleroticAnimalsAtherosclerosisDisease Models, AnimalHumansMaleMiceMice, Inbred C57BL
Identifiers
PMID
40263614What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.