Evidence map›Paper›PMID 40263398›Full record

ArticleScientific reports2025

Biocatalytic production of 3-hydroxypropionic acid precursors using a regioselective Baeyer-Villiger monooxygenase.

Melissa De Angelis, Danilo Correddu, Fabio Bucciol, Silvia Tabasso, Gianluca Catucci, Giancarlo Cravotto, Carlo Roggero, Gianfranco Gilardi, Sheila J Sadeghi

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Melissa De AngelisDepartment of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, Torino, 10123, Italy.
Danilo CorredduDepartment of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, Torino, 10123, Italy.
Fabio BucciolDepartment of Drug Science and Technology, University of Torino, Via Pietro Giuria 9, Torino, 10125, Italy.
Silvia TabassoDepartment of Drug Science and Technology, University of Torino, Via Pietro Giuria 9, Torino, 10125, Italy.
Gianluca CatucciDepartment of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, Torino, 10123, Italy.
Giancarlo CravottoDepartment of Drug Science and Technology, University of Torino, Via Pietro Giuria 9, Torino, 10125, Italy.
Carlo RoggeroSea Marconi Technologies S. a. s., Via Ungheria 20, Collegno, 10093, Italy.
Gianfranco GilardiDepartment of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, Torino, 10123, Italy.
Sheila J SadeghiDepartment of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, Torino, 10123, Italy. sheila.sadeghi@unito.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Baeyer-Villiger monooxygenases (BVMOs) are versatile biocatalysts that catalyse the oxidation of ketones to esters with high regio- and enantioselectivity, operating under mild reaction conditions while reducing hazardous waste. Some BVMOs can convert cellulose-derived alkyl levulinates to 3-acetoxypropionates (3-APs), which are key intermediates in the production of 3-hydroxypropionic acid (3-HP), a versatile building block chemical. In this study, a BVMO from Acinetobacter radioresistens (Ar-BVMO) was tested as a biocatalyst for the conversion of three marketed alkyl levulinates: methyl, ethyl and butyl levulinate. The enzyme showed 4-fold higher catalytic efficiency (k

Indexed as

AcinetobacterLactic AcidMixed Function OxygenasesBiocatalysisEscherichia coliLevulinic AcidsOxidation-ReductionStereoisomerismSubstrate Specificityhydracrylic acidLactic AcidLevulinic AcidsMixed Function Oxygenases3-hydroxypropionic acidAlkyl levulinatesBaeyer-VilligerBiocatalysisMonooxygenasePulp

Identifiers

PMID40263398
PMCPMC12015234

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.