ArticleNPJ Parkinson's disease2025
Patterns of cerebellar cortex hypermetabolism on motor and cognitive functions in PD.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- A Distributed Oscillatory Network Model of Parkinsonian Tremor: Integrating Basal Ganglia and Cerebello-Thalamic Circuits.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Review
- Multimodal data-driven eye-movement subtypes and their cerebral glucose metabolic patterns in Parkinson's disease.Frontiers in aging neuroscience · 2026Article
- Multi-omic analysis reveals lipid dysregulation associated with mitochondrial dysfunction in parkinson's disease brain.Nature communications · 2025Article
- Contribution of Cerebellar Glutamatergic and GABAergic Systems in Premotor and Early Stages of Parkinson's Disease.International journal of molecular sciences · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
Abstract
Previous studies suggest the cerebellum may play a role in both motor and non-motor symptoms of Parkinson's disease (PD), though molecular evidence remains insufficient. We enrolled 104 PD patients to analyze the correlation between cerebellar glucose metabolism and motor and cognitive functions. Metabolic differences across motor subtypes and cognitive stages were examined, along with their relationship to supratentorial structures. Results showed that glucose metabolism in left cerebellar lobules IV and V was negatively correlated with motor function, with no significant differences between tremor-dominant (TD) and postural instability gait difficulty (PIGD) groups. Metabolism in lobules VI, VIII, and the dentate nucleus negatively correlated with cognitive function, with significant differences across cognitive stages. Cerebellar metabolism was closely linked to the cerebral cortex, and a correlation with the thalamus was observed in the TD group. These findings suggest cerebellar glucose metabolism may reflect compensatory mechanisms, highlighting the cerebellum as a potential therapeutic target.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.