ArticleNPJ science of food2025
Regulatory effects of Poria cocos polysaccharides on gut microbiota and metabolites: evaluation of prebiotic potential.
Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Modulation of the gut microbiota by traditional Chinese medicine to attenuate chemotherapy-induced toxicity in gastric cancer: a review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Review
- Mapping the Research Landscape ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Gypenosides Mitigate STEC-Induced Intestinal Injury Through Modulation of Ferroptosis Involving the ATF4-CHAC1-GPX4 Axis.Antioxidants (Basel, Switzerland) · 2026Article
- Phytochemicals remodel antitumor immunity via the "microbiota-metabolite-receptor" axis: focus on colorectal cancer and immunotherapy.Medical oncology (Northwood, London, England) · 2026Review
- Effects of Traditional Chinese Herbal Extracts on Tear Staining, Iron Status, Immune Function, and Antioxidant Capacity in Dogs.Animals : an open access journal from MDPI · 2026Article
- Immune-related core gene identification in irritable bowel syndrome and prediction of regulatory traditional Chinese medicines.Medicine · 2026Article
- Phytochemical Profiling and Characterization of Honeydew, Cantaloupe, and Galia Melon Peel Extracts for Potential Prebiotic Activities.Food science & nutrition · 2026Article
- Annealing-FabricatedGels (Basel, Switzerland) · 2026Article
- Gut Microbiota-Mediated Mechanisms of Traditional Chinese Medicine in Obesity Management.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- Modulation of the microbiota-lipid-brain axis by modified Chaihu-Longgu-Muli Decoction ameliorates chronic stress-induced depression.Frontiers in molecular neuroscience · 2026Article
- Preventing ventilator-associated pneumonia via the gut-lung axis: the Shenling Baizhu San hypothesis.Frontiers in medicine · 2026Article
- Research progress on the pharmacological effects ofFrontiers in nutrition · 2026Review
- Integrated metabolomics and computational analysis suggest that aFrontiers in nutrition · 2026Article
- Article
- In Vitro Assessment of the Prebiotic Effects of Poria Cocos Polysaccharides Using Fecal Microbiota from Normal-Weight and Obese Children.Foods (Basel, Switzerland) · 2025Article
- Optimization of Its Preparation and Evaluation of Fresh and Tender Leaves ofFoods (Basel, Switzerland) · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
Dietary polysaccharides have long been recognized for their capacity to modulate gut microbiota composition and metabolic activities, making them promising resources for functional food development. In this study, we investigated the effects of Poria cocos (P. cocos) polysaccharides on the structure and metabolism of human gut microbiota using an in vitro fecal fermentation model. Our results revealed that P. cocos polysaccharides were readily utilized by the gut microbiota, as evidenced by a significant decrease in pH and an increase in SCFAs concentrations. Notably, the relative abundance of beneficial bacteria (e.g., Lactobacillus and Bifidobacterium) increased, whereas that of potentially pathogenic taxa (e.g., Escherichia-Shigella and Bilophila) decreased. Furthermore, P. cocos polysaccharides enhanced the production of key microbial metabolites, significantly upregulating compounds such as L-cystine and etelcalcetide. Collectively, these findings underscore the beneficial role of P. cocos polysaccharides in promoting intestinal health and highlight their potential as prebiotics in the functional food industry.
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Registered trials
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