Evidence map›Paper›PMID 40263343›Full record

ArticleScientific reports2025

Identification of potential SARS-CoV-2 inhibitors among well-tolerated drugs using drug repurposing and in vitro approaches.

Betül Oruçoğlu, İdil Çetin, Handan Şimşek, Mehmet Topçul, Mahmut Çalışkan, Cihan Aydın, I Halil Kavaklı, Alper Okyar, Şeref Gül

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Betül OruçoğluBiotechnology Division, Department of Biology, Istanbul University, Istanbul, Türkiye.
İdil ÇetinBiotechnology Division, Department of Biology, Istanbul University, Istanbul, Türkiye.
Handan ŞimşekBiotechnology Division, Department of Biology, Istanbul University, Istanbul, Türkiye.
Mehmet TopçulBiotechnology Division, Department of Biology, Istanbul University, Istanbul, Türkiye.
Mahmut ÇalışkanBiotechnology Division, Department of Biology, Istanbul University, Istanbul, Türkiye.
Cihan AydınDepartment of Molecular Biology, Faculty of Engineering and Natural Sciences, Istanbul Medeniyet University, Istanbul, Türkiye.
I Halil KavaklıDepartment of Molecular Biology and Genetics, Koc University, Istanbul, Türkiye.
Alper OkyarFaculty of Pharmacy, Department of Pharmacology, İstanbul University, Istanbul, Türkiye.
Şeref GülInstitute of Life Sciences and Biotechnology, Bezmialem Vakif University, Istanbul, Türkiye. seref.gul@bezmialem.edu.tr.

Funding

Bilimsel Araştirma Projeleri Birimi, Istanbul Üniversitesi FYL-2023-40043Türkiye Bilimsel ve Teknolojik Araştırma Kurumu 221Z267
6 · The paper itself

Abstract

The 3C-like protease (3CL

Indexed as

Antiviral AgentsCoronavirus 3C ProteasesCOVID-19 Drug TreatmentDrug RepositioningSARS-CoV-2Caco-2 CellsCOVID-19HumansVirus Replication3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C Proteases3CLproCandesartanDrug repurposingLumacaftorSARS-CoV-2Subgenomic replicon

Identifiers

PMID40263343
PMCPMC12015351

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.