Evidence map›Paper›PMID 40263282›Full record

ArticleNature communications2025

Boosting hydrogel conductivity via water-dispersible conducting polymers for injectable bioelectronics.

Hossein Montazerian, Elham Davoodi, Canran Wang, Farnaz Lorestani, Jiahong Li, Reihaneh Haghniaz, Rohan R Sampath, Neda Mohaghegh, Safoora Khosravi, Fatemeh Zehtabi and 10 more

Erratum issuedAbstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Conductive Hydrogels for Exogenous Sensing and Cell Fate Control.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  15. Review
  16. Article
  17. Materials and System Design for Self-Decision Bioelectronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Hossein Montazerian *David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID http://orcid.org/0000-0001-6972-2667
Elham Davoodi *Mechanical Engineering Department, University of Utah, Salt Lake City, Utah, USA.
Canran WangAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, California, USA.
Farnaz LorestaniDepartment of Engineering Science and Mechanics, Pennsylvania State University, University Park, Pennsylvania, USA.
Jiahong LiAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, California, USA.
Reihaneh HaghniazTerasaki Institute for Biomedical Innovation, Los Angeles, California, USA.
Rohan R SampathDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California, USA.ORCID http://orcid.org/0009-0009-2419-0842
Neda MohagheghTerasaki Institute for Biomedical Innovation, Los Angeles, California, USA.
Safoora KhosraviTerasaki Institute for Biomedical Innovation, Los Angeles, California, USA.
Fatemeh ZehtabiTerasaki Institute for Biomedical Innovation, Los Angeles, California, USA.
Yichao ZhaoDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Negar HosseinzadehTerasaki Institute for Biomedical Innovation, Los Angeles, California, USA.
Tianhan LiuDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California, USA.ORCID http://orcid.org/0000-0003-3934-0785
Tzung K HsiaiDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, California, USA.ORCID http://orcid.org/0000-0003-1734-0792
Alireza Hassani NajafabadiTerasaki Institute for Biomedical Innovation, Los Angeles, California, USA. hassania@terasaki.org.ORCID http://orcid.org/0000-0002-8215-4374
Robert LangerDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID http://orcid.org/0000-0003-4255-0492
Daniel G AndersonDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID http://orcid.org/0000-0001-5629-4798
Paul S WeissDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, California, USA. psw@cnsi.ucla.edu.
Ali KhademhosseiniTerasaki Institute for Biomedical Innovation, Los Angeles, California, USA. khademh@terasaki.org.ORCID http://orcid.org/0000-0002-2692-1524
Wei GaoAndrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, California, USA. weigao@caltech.edu.ORCID http://orcid.org/0000-0002-8503-4562

Funding

Intravascular Deployment of a Wirelessly Powered Micro-PacerR01HL149808 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Tzung K Hsiai · 2020 to 2026
$2.8M
Engineering highly elastic surgical sealants with hemostatic propertiesR01HL140618 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNABI, NASIM, KHADEMHOSSEINI, ALI · 2018 to 2021
$2.8M
Engineering a naturally derived and highly adhesive surgical sealantR01EB023052 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNABI, NASIM, KHADEMHOSSEINI, ALI · 2017 to 2022
$2.4M
SMART BIOELECTRONIC IMPLANTS FOR CONTROLLED DELIVERY OF THERAPEUTIC PROTEINS IN VIVO AND ITS APPLICATION IN LONG-TERM TREATMENT OF HEMOPHILIA AR01EB031992 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ANDERSON, DANIEL G · 2022 to 2025
$2.4M
Laser-Engraved Wearable Sweat Sensors to Detect and Monitor Cardiometabolic DiseaseR01HL155815 · NHLBI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GAO, WEI · 2021 to 2025
$2.0M
Caltech/UCLA Individualized Theranostic Engineering to Advance Metabolic System (iTEAM)T32EB027629 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Dino Di Carlo, Azita Emami · 2020 to 2026
$2.0M
Develop a wireless, skin-conformable and dual-sensing wearable system in support of voice and upper airway telehealth careR01DC021461 · NIDCD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Wei Gao, Jianyu Li · 2024 to 2026
$1.8M
NHLBI NIH HHS R01 HL140618NHLBI NIH HHS R01 HL149808NHLBI NIH HHS R01 HL155815NIBIB NIH HHS R01 EB023052NIBIB NIH HHS R01 EB031992NIBIB NIH HHS T32 EB027629NIDCD NIH HHS R01 DC021461U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01DC021461U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01EB023052U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01EB031992U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01HL140618U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32EB023858
6 · The paper itself

Abstract

Bioelectronic devices hold transformative potential for healthcare diagnostics and therapeutics. Yet, traditional electronic implants often require invasive surgeries and  are mechanically incompatible with biological tissues. Injectable hydrogel bioelectronics offer a minimally invasive alternative that interfaces with soft tissue seamlessly. A major challenge is the low conductivity of bioelectronic systems, stemming from poor dispersibility of conductive additives in hydrogel mixtures. We address this issue by engineering doping conditions with hydrophilic biomacromolecules, enhancing the dispersibility of conductive polymers in aqueous systems. This approach achieves a 5-fold increase in dispersibility and a 20-fold boost in conductivity compared to conventional methods. The resulting conductive polymers are molecularly and in vivo degradable, making them suitable for transient bioelectronics applications. These additives are compatible with various hydrogel systems, such as alginate, forming ionically cross-linkable conductive inks for 3D-printed wearable electronics toward high-performance physiological monitoring. Furthermore, integrating conductive fillers with gelatin-based bioadhesive hydrogels substantially enhances conductivity for injectable sealants, achieving 250% greater sensitivity in pH sensing for chronic wound monitoring. Our findings indicate that hydrophilic dopants effectively tailor conducting polymers for hydrogel fillers, enhancing their biodegradability and expanding applications in transient implantable biomonitoring.

Indexed as

HydrogelsPolymersAlginatesAnimalsBiocompatible MaterialsElectric ConductivityGelatinHumansInjectionsPrinting, Three-DimensionalWaterWearable Electronic DevicesAlginatesBiocompatible MaterialsGelatinHydrogelsPolymersWater

Identifiers

PMID40263282
PMCPMC12015517

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.