ReviewBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2025
The role of corroles in modern cancer therapy: innovation and prospects.
Review in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- SIRT1 Modulates the Photodynamic Anticancer Activity of 5,10,15-Triethoxycarbonyl P(V) Corrole in Hepatocellular Carcinoma.Pharmaceuticals (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Corroles, a class of tetrapyrrolic macrocycles, have garnered significant attention for their potential in cancer therapy due to their unique structural chemistry and ability to coordinate with metals. Their remarkable photophysical properties make them beneficial for photodynamic therapy (PDT) and fluorescence imaging, as they can produce reactive oxygen species when activated by light, offering potential for the treatment of various carcinomas, including hepatic, breast, pancreatic, and lung cancers. Despite the encouraging preclinical and clinical data supporting their therapeutic efficacy, challenges remain in optimizing corrole formulations, particularly concerning targeted delivery, stability, and bioavailability. This review highlights current advancements in corrole-based therapies, focusing on novel nanoparticle formulations that enhance drug distribution and therapeutic efficacy. Furthermore, it examines the mechanisms of corrole-mediated cellular death and the role of photodynamic treatment in inducing apoptosis via various signaling pathways. Additional research is necessary to address formulation-related issues while ensuring the safety and effectiveness of corroles in cancer treatment, therefore maximizing their therapeutic potential and adhering to regulatory standards.
Indexed as
Identifiers
40263217What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.