Evidence map›Paper›PMID 40263199›Full record

Observational studyInternational journal of colorectal disease2025

A 22-year experience of surgical management of anorectal melanoma: risk factors for recurrence and death.

Richard Sassun, David W Larson, Annaclara Sileo, Jyi Cheng Ng, Davide Ferrari, Nicholas P McKenna, William R G Perry

Erratum issuedAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of colorectal disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Richard Sassun *Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA. richard.sassun@unimi.it.
David W LarsonDivision of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA.
Annaclara Sileo *Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA.
Jyi Cheng NgDivision of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA.
Davide FerrariDivision of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA.
Nicholas P McKennaDivision of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA.
William R G PerryDivision of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAnorectal melanoma (ARM) poses a significant challenge due to the lack of established guidelines and a 5-year overall survival rate of less than 20%. The only recognized death risk factors are positive lymph nodes and positive surgical margins. This study aimed to identify the risk factors for local/distant recurrences and death in a 22-year multi-institutional experience.

methodsAll patients who underwent curative surgical resection or were referred to after resection at the Mayo Clinic for non-metastatic ARM (2002-2024) were included. Risk factors for local/distant recurrences, and deaths were assessed through multivariable Cox regression.

resultsEighty-eight patients were included in the study. Seventy-eight percent of patients had anal melanoma and 22% rectal melanoma. Nineteen percent had clinically positive lymph nodes. The surgical margins were positive in 62% of local surgeries, while they were positive in 13% of radical surgery cases. The first recurrence was often a local recurrence (67%), followed by distant metastasis (21%), with an overall comparable overall survival between the two. Radiotherapy administration, radical surgery, and negative margins were associated with less local recurrence. Clinically positive lymph nodes and local recurrences increased the risk of developing distant metastasis over time. Clinically negative lymph nodes, radiotherapy administration, radical surgery, and negative margins all contributed to a reduced death risk.

conclusionLocal recurrences in ARM may influence distant metastasis and death more than what was previously believed. Positive surgical margins in local surgery were remarkably high, reaching 62%. Protective factors for local recurrence and death included radical surgery, negative surgical margins, and radiotherapy.

Indexed as

Anus NeoplasmsMelanomaNeoplasm Recurrence, LocalRectal NeoplasmsAdultAgedAged, 80 and overFemaleHumansLymphatic MetastasisMaleMargins of ExcisionMiddle AgedProportional Hazards ModelsRisk FactorsTime FactorsAnorectal melanomaImmunotherapyMarginsRadiotherapyRecurrenceSurvival

Identifiers

PMID40263199
PMCPMC12014828

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.