Evidence map›Paper›PMID 40262965›Full record

ArticleBMJ open2025

TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): protocol for a prospective observational cohort study of concussion patients with embedded comparative effectiveness research within a network of learning health system concussion clinics in Canada.

Roger Zemek, Lisa M Albrecht, Sharon Johnston, John Leddy, Andrée-Anne Ledoux, Nick Reed, Noah Silverberg, Keith Yeates, Monica Lamoureux, Charlotte Anderson and 32 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07636408 (Enhancing Sleep to Improve Brain-heart Functions in People With Persistent Post-concussion Symptoms), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07636408 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Enhancing Sleep to Improve Brain-heart Functions in People With Persistent Post-concussion Symptoms

TypeinterventionalSponsorUniversity of OttawaRan2026 to 2027Enrolled70ConditionsInsomnia, Concussion Post SyndromeArmsCBT-pI, Sleep Hygiene
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

Roger ZemekChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada rzemek@cheo.on.ca.ORCID http://orcid.org/0000-0001-7807-2459
Lisa M AlbrechtChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.ORCID http://orcid.org/0000-0003-0584-4969
Sharon JohnstonFaculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.ORCID http://orcid.org/0000-0001-8382-0378
John LeddyJacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.ORCID http://orcid.org/0000-0002-0370-1289
Andrée-Anne LedouxChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
Nick ReedRehabilitation Sciences Institute, University of Toronto, Toronto, Ontario, Canada.
Noah SilverbergFaculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0001-6378-148X
Keith YeatesAlberta Children's Hospital Research Institute, Calgary, Alberta, Canada.ORCID http://orcid.org/0000-0001-7680-2892
Monica LamoureuxChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
Charlotte AndersonPhysical Therapy, University of Toronto, Toronto, Ontario, Canada.
Nicholas BarrowmanChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
Miriam H BeauchampPsychology, University of Montreal, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0002-8637-6361
Kitty ChenChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.ORCID http://orcid.org/0009-0007-0624-1867
Araba ChintohPsychiatry, University of Calgary, Calgary, Alberta, Canada.
Achelle Cortel-LeBlancFaculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Miguel Cortel-LeBlancFaculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Daniel J CorwinThe Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID http://orcid.org/0000-0003-2157-3644
Stephanie CowleParachute, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-1940-6786
Kristine DaltonSchool of Optometry & Vision Science, University of Waterloo, Waterloo, Ontario, Canada.ORCID http://orcid.org/0000-0002-2616-4797
Jennifer DawsonChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
Andrew DoddChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.ORCID http://orcid.org/0000-0001-9261-4090
Khaled El EmamChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.ORCID http://orcid.org/0000-0003-3325-4149
Carolyn EmeryAlberta Children's Hospital Research Institute, Calgary, Alberta, Canada.
Erin FoxIKT/Patient Engagement, Ottawa, Ontario, Canada.
Pamela FuselliParachute, Toronto, Ontario, Canada.
Isabelle J GagnonSchool of Physical and Occupational Therapy, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0003-2043-1644
Christopher GizaPediatrics, Neurosurgery, UCLA Brain Injury Research Center, Los Angeles, California, USA.
Steven HicksPenn State College of Medicine, Hershey, Pennsylvania, USA.
David R HowellUniversity of Colorado Denver School of Medicine, Aurora, Colorado, USA.ORCID http://orcid.org/0000-0002-2955-0191
Stephen Alexander KutcherChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
Carlos LalondeHomewood Health, Guelph, Ontario, Canada.
Rebekah C MannixPediatrics, Boston Children's Hospital, Boston, Massachusetts, USA.
Christina L MasterThe Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID http://orcid.org/0000-0002-6717-4270
Andrew R MayerUniversity of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Martin H OsmondChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
Rebecca RobillardSleep Research Unit, Institute for Mental Health Research, Ottawa, Ontario, Canada.ORCID http://orcid.org/0000-0002-1491-997X
Kathryn J SchneiderAlberta Children's Hospital Research Institute, Calgary, Alberta, Canada.
Peter TanuseputroUniversity of Hong Kong Faculty of Medicine, Hong Kong.
Ivan TerekhovChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
Richard WebsterChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
Cheryl Lea WellingtonFaculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0001-7014-039X
TRANSCENDENT Concussion Integrated Discovery Program

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionConcussion affects over 400 000 Canadians annually, with a range of causes and impacts on health-related quality of life. Research to date has disproportionately focused on athletes, military personnel and level I trauma centre patients, and may not be applicable to the broader community. The TRANSCENDENT Concussion Research Program aims to address patient- and clinician-identified research priorities, through the integration of clinical data from patients of all ages and injury mechanisms, patient-reported outcomes and objective biomarkers across factors of intersectionality. Seeking guidance from our Community Advisory Committee will ensure meaningful patient partnership and research findings that are relevant to the wider concussion community. METHODS AND ANALYSIS: This prospective observational cohort study will recruit 5500 participants over 5 years from three 360 Concussion Care clinic locations across Ontario, Canada, with a subset of participants enrolling in specific objective assessments including testing of autonomic function, exercise tolerance, vision, advanced neuroimaging and fluid biomarkers. Analysis will be predicated on pre-specified research questions, and data shared with the Ontario Brain Institute's Brain-CODE database. This work will represent one of the largest concussion databases to date, and by sharing it, we will advance the field of concussion and prevent siloing within brain health research. ETHICS AND DISSEMINATION: This study was approved by the Children's Hospital of Eastern Ontario Research Ethics Board and preregistered on OSF (25 June 2024); https://doi.org/10.17605/OSF.IO/HYDZC. Dissemination of findings will be multifaceted, including conference presentations, peer-reviewed publications and sharing of adapted materials (eg, videos, infographics, plain language summaries) with community groups and key knowledge users.

Indexed as

Brain ConcussionCanadaComparative Effectiveness ResearchData CollectionHumansObservational Studies as TopicOntarioProspective StudiesResearch DesignBrain InjuriesEPIDEMIOLOGYObservational StudyREGISTRIES

Identifiers

PMID40262965
PMCPMC12015710

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.