Evidence map›Paper›PMID 40262958›Full record

ArticleBMJ open2025

Molecular epidemiology of dengue in Southeast Asia (SEA): Protocol of systematic review and meta-analysis.

Lonny Chen Rong Qi Ahmad, Balvinder Singh Gill, Lokman Hakim Sulaiman, Nor Asiah Muhamad, Sarbhan Singh, Kok Keng Tee, Teguh Haryo Sasongko, Kenny Gah Leong Voon, Sumarni Mohd Ghazali, Nur Hasnah Maamor and 3 more

Abstract read
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lonny Chen Rong Qi AhmadInstitute of Medical Research, National Institutes of Health Malaysia, Shah Alam, Selangor, Malaysia lonny@moh.gov.my.ORCID http://orcid.org/0000-0002-1478-2846
Balvinder Singh GillInstitute of Medical Research, National Institutes of Health Malaysia, Shah Alam, Selangor, Malaysia.
Lokman Hakim SulaimanInstitute for Research, Development and Innovation, IMU University, Kuala Lumpur, Malaysia.
Nor Asiah MuhamadSector for Evidence Based Healthcare, National Institutes of Health Malaysia, Shah Alam, Selangor, Malaysia.ORCID http://orcid.org/0000-0002-7772-2103
Sarbhan SinghInstitute of Medical Research, National Institutes of Health Malaysia, Shah Alam, Selangor, Malaysia.
Kok Keng TeeDepartment of Medical Microbiology, Faculty of Medicine University Malaya, Kuala Lumpur, Malaysia.
Teguh Haryo SasongkoInstitute for Research, Development and Innovation, IMU University, Kuala Lumpur, Malaysia.
Kenny Gah Leong VoonNottingham University Malaysia, School of Pharmacy, Malaysia Campus, Semenyih, Selangor, Malaysia.
Sumarni Mohd GhazaliInstitute of Medical Research, National Institutes of Health Malaysia, Shah Alam, Selangor, Malaysia.ORCID http://orcid.org/0000-0001-5230-9569
Nur Hasnah MaamorSector for Evidence Based Healthcare, National Institutes of Health Malaysia, Shah Alam, Selangor, Malaysia.
Nur Ar Rabiah AhmadInstitute of Medical Research, National Institutes of Health Malaysia, Shah Alam, Selangor, Malaysia.
Nurul Izzah Ahamad ZambriInstitute of Medical Research, National Institutes of Health Malaysia, Shah Alam, Selangor, Malaysia.
Mei Cheng LimInstitute of Medical Research, National Institutes of Health Malaysia, Shah Alam, Selangor, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDengue fever is a major global public health challenge caused by the Arbovirus and transmitted by Aedes mosquitoes. The increasing incidence of dengue, particularly in the Southeast Asia (SEA) region, including Malaysia, highlights the urgent need for a comprehensive understanding of dengue molecular epidemiology. This study aims to systematically review various aspects of dengue molecular epidemiology to gain insights into the disease's dynamics, transmission and circulation. Providing evidence-based insights is crucial for the prevention and control of dengue. METHODS AND ANALYSIS: A systematic review and meta-analysis will be conducted following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guidelines. Eligible studies will include observational designs from the inception of time to 31 December 2024, in the SEA region. The review will encompass various molecular epidemiology domains as the exposures and assess the outcomes, such as confirmed dengue cases and severity. Descriptive and meta-analytical methods will determine prevalence, genetic changes and associations. Grading of Recommendations Assessment, Development, and Evaluation methodology will evaluate the quality of evidence, and reporting biases will be addressed. This review aims to bridge the gap in dengue molecular epidemiology in the SEA region by providing comprehensive insights crucial for effective dengue prevention and control. ETHICS AND DISSEMINATION: No primary data will be collected; thus, the ethical exemption was obtained from Medical Research Ethics Committee with reference number 23-03212-AE6 and ethics approval from the IMU University Joint Committee. The results will be disseminated through a peer-reviewed publication and conference presentation. PROSPERO REGISTRATION NUMBER: CRD42023480417.

Indexed as

DengueDengue VirusAedesAsia, SoutheasternHumansMeta-Analysis as TopicMolecular EpidemiologyResearch DesignSystematic Reviews as TopicEpidemiologyMeta-AnalysisMOLECULAR BIOLOGYPUBLIC HEALTHSystematic ReviewVIROLOGY

Identifiers

PMID40262958
PMCPMC12015693

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.