Evidence map›Paper›PMID 40262793›Full record

ArticlePsychiatry investigation2025

Frontal and Parietal Alpha Asymmetry as Biomarkers for Negative Symptoms in Schizophrenia.

Yao-Cheng Wu, Chih-Chung Huang, Yi-Guang Wang, Chu-Ya Yang, Wei-Chou Chang, Chuan-Chia Chang, Hsin-An Chang

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Article in Psychiatry investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Yao-Cheng WuDepartment of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chih-Chung HuangDepartment of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Yi-Guang WangDepartment of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chu-Ya YangDepartment of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Wei-Chou ChangDepartment of Radiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chuan-Chia ChangDepartment of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Hsin-An ChangDepartment of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Funding

Ministry of National Defense MND-MAB-113100Ministry of National Defense MND-MAB-D-112164National Science and Technology Council of Taiwanese Government NSTC-112-2314-B-016-017-MY3Tri-Service General Hospital TSGH-D-112118Tri-Service General Hospital TSGH-D-113149
6 · The paper itself

Abstract

objectiveNegative symptoms in schizophrenia indicate a poor prognosis. However, the mechanisms underlying the development of negative symptoms remain unclear. This study investigated the relationship between negative symptoms in schizophrenia and frontal alpha asymmetry (FAA).

methodsThe study used a 32-channel electroencephalography to acquire alpha power in 4 target-paired sites in each patient. Regional alpha asymmetry was calculated based on the alpha power using EEGLAB Frontal Alpha Asymmetry Toolbox.

resultsSixty schizophrenia patients with predominant negative symptoms (PNS), 72 stabilized schizophrenia (SS) patients, and 73 healthy control (HC) participants were enrolled in this study. No significant differences were observed in FAA between the PNS and SS groups, although both groups exhibited reduced P3-P4 alpha asymmetry compared to HCs. A positive correlation was found between F7-F8 alpha asymmetry and illness duration. Additionally, a predictive model based on P3-P4 alpha asymmetry scores was able to differentiate schizophrenia patients from HCs, achieving a sensitivity of 71.2% and a specificity of 72.6%.

conclusionThis study highlighted that parietal alpha asymmetry could serve as a valuable diagnostic tool for schizophrenia.

Indexed as

Alpha rhythmEEGFunctional lateralityNegative symptomsSchizophrenia

Identifiers

PMID40262793
PMCPMC12022788

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