ArticleThe Plant cell2025
The transcription factors DOF4.6 and XND1 jointly regulate root hydraulics and drought responses in Arabidopsis.
Article in The Plant cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A GWAS-identified U-box E3 ligase MsPUB6 is positively regulated by MsDREB1C and contributes to drought tolerance in alfalfa.Plant physiology · 2026Article
- Dof Transcription Factors as Integrative Regulatory Hubs Linking Carbon-Nitrogen Metabolism, Development, and Environmental Signaling in Plants.Plant, cell & environment · 2026Review
- The SlDOF3.4-SlCDF4 module improves tomato growth under low-nitrogen conditions.Horticulture research · 2026Article
- Article
- NUT1-Exo70A1 Regulates Xylem Vessel Development and Influences Water Use Efficiency in Maize.Nature communications · 2026Article
- Genome-Wide Identification and Expression Analysis of LBD Gene Family inInternational journal of molecular sciences · 2026Article
- Integrated transcriptomic and metabolomic analysis of provenances and organ-specific responses to drought and rehydration inFrontiers in plant science · 2026Article
- Integrated metabolome and transcriptome analyses reveal the response mechanism under drought stress ofFrontiers in plant science · 2026Article
- Evolutionary analysis of the Dof family in plants and identification of its members in tobacco.Frontiers in plant science · 2026Article
- SoybeanPlants (Basel, Switzerland) · 2025Article
- Genome-Wide Analysis of theInternational journal of molecular sciences · 2025Article
- A helping hand: XND1-DOF4.6 interaction modulates Arabidopsis drought tolerance.The Plant cell · 2025Article
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Authors and funding
10 authors.
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Abstract
Water uptake by roots is essential for plant growth and stress acclimation. We previously showed that the XYLEM NAC DOMAIN 1 (XND1) transcription factor negatively regulates root hydraulic conductivity (Lpr) in Arabidopsis (Arabidopsis thaliana). Here, we show that XND1 physically interacts with the transcription factor DNA-binding with One Finger 4.6 (DOF4.6). Analyses of loss-of-function mutants and overexpression lines revealed that, similar to XND1, DOF4.6 negatively regulates Lpr. DOF4.6 and XND1 jointly modulate downstream gene expression, inhibiting root xylem formation. Notably, DOF4.6 facilitates XND1 binding to the promoter of XYLEM CYSTEINE PROTEASE 1, the product of which controls programmed cell death during xylem development. DOF4.6 also independently binds to the promoters of the aquaporins PIP2;5 and PIP2;6, thereby suppressing their expression and exerting potential direct regulatory effects on membrane water transport. Importantly, the dof4.6 loss-of-function alleles showed significantly enhanced resistance to drought stress. Collectively, our findings demonstrate that DOF4.6 plays a crucial role in root hydraulics and drought stress responses, partially in concert with XND1 and through combined effects on xylem formation and aquaporin functions.
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