Evidence map›Paper›PMID 40262694›Full record

ArticleArchives of biochemistry and biophysics2025

Calcium-dependent levels of phospholamban pentamer in native heart membranes reflect interactions of monomers with calcium-free SERCA2a.

Jin Guo, Kazuhiro Aonuma, Richard Kovacs, Zhenhui Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jin GuoKrannert Cardiovascular Research Center, Indiana University, Indianapolis, IN, USA.
Kazuhiro AonumaKrannert Cardiovascular Research Center, Indiana University, Indianapolis, IN, USA.
Richard KovacsKrannert Cardiovascular Research Center, Indiana University, Indianapolis, IN, USA.
Zhenhui ChenKrannert Cardiovascular Research Center, Indiana University, Indianapolis, IN, USA. Electronic address: zhechen@iu.edu.

Funding

Critical Sorting Steps and Pathways in the Trafficking of Cardiac Sarcoplasmic Reticulum ProteinsR01HL169877 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Zhenhui Chen · 2023 to 2026
$2.6M
NHLBI NIH HHS R01 HL169877
6 · The paper itself

Abstract

backgroundIn sarcoplasmic reticulum (SR) membranes, phospholamban (PLB) exists in an equilibrium of non-inhibitory homopentamers (PLB

methodsDog cardiac SR membranes (dSR) were switched between EGTA and Ca

resultsConverting SERCA2a from E2 to E1, Ca

conclusionsWe have developed a simple, effective method and revealed that the levels of SERCA2a inhibition are controlled by an equilibrium between PLB

Indexed as

CalciumCalcium-Binding ProteinsMyocardiumSarcoplasmic ReticulumSarcoplasmic Reticulum Calcium-Transporting ATPasesAnimalsDogsPhospholambanProtein BindingProtein MultimerizationCalciumCalcium-Binding ProteinsPhospholambanSarcoplasmic Reticulum Calcium-Transporting ATPasesCalcium ATPaseexcitation‐contraction coupling (E-C coupling)Membrane proteinPhospholambanProtein kinase A (PKA)Protein-protein interactionsSarcoplasmic reticulum (SR)Stoichiometry

Identifiers

PMID40262694
PMCPMC12090653

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.