Evidence map›Paper›PMID 40262633›Full record

ArticleNature2025

Substrate recognition and cleavage mechanism of the monkeypox virus core protease.

Yan Gao, Xiong Xie, Xiaoyu Zhang, Junyuan Cao, Weiqi Lan, Tian You, Dongxu Li, Xuxue Dong, Wenhao Dai, Yingchun Xiang and 28 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Yan Gao *Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID 0000-0002-0364-6427
Xiong Xie *State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0003-1685-867X
Xiaoyu Zhang *Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Junyuan Cao *CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Weiqi Lan *Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Tian You *Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID 0000-0003-0555-6916
Dongxu Li *Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Xuxue Dong *Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID 0009-0004-7661-0291
Wenhao DaiState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Yingchun XiangHubei Jiangxia Laboratory, Wuhan, China.
Shulei HuState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Weijuan ShangCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Botao WuState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.ORCID 0009-0006-8773-9212
Yumin ZhangCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.ORCID 0000-0003-0767-1221
Jin XuShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Xiaoce LiuShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Haofeng WangShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Wanlong HuShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Mingjing ZhangShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Yinkai DuanShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID 0000-0002-0544-7413
Wen CuiCollege of Pharmacy, Chongqing Medical University, Chongqing, China.
Hao ZhouShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID 0000-0002-9060-6959
Shengjiang MaoShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Handi JiaShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Zhanqi SunShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Menghan JiaShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID 0009-0009-4398-9625
Yue YinNational Facility for Protein Science in Shanghai, Shanghai Advanced Research Institute, Chinese Academy of Science, Shanghai, China.ORCID 0000-0002-7693-3910
Henry C NguyenShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID 0000-0002-6142-8807
Kailin YangTaussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA.
Bei YangShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID 0000-0001-5389-3859
Xiuna YangShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID 0000-0003-3443-9815
Xiaoyun JiState Key Laboratory of Pharmaceutical Biotechnology, Department of Biotechnology and Pharmaceutical Sciences, School of Life Sciences, Nanjing University, Nanjing, China.ORCID 0000-0002-0801-8825
Gengfu XiaoCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.ORCID 0000-0001-9401-235X
Wei WangCollege of Pharmacy, Chongqing Medical University, Chongqing, China. wangwei@cqmu.edu.cn.ORCID 0000-0002-2870-0733
Leike ZhangCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. zhangleike@wh.iov.cn.ORCID 0000-0002-2593-2571
Zihe RaoLaboratory of Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China. raozh@mail.tsing-hua.edu.cn.ORCID 0000-0001-9866-2384
Hong LiuShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China. hliu@simm.ac.cn.ORCID 0000-0003-3685-6268
Haitao YangShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China. yanght@shanghaitech.edu.cn.ORCID 0000-0002-1875-3268

Funding

Chongqing Municipal Education CommissionChongqing Science and Technology BureauHubei Natural Science Foundation for Distinguished Young ScholarsJoint Funds of the National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaShanghai Municipal Science and Technology Major ProjectShanghai Rising Star ProgramStrategic Priority Research Program of Chinese Academy of Sciences
6 · The paper itself

Abstract

Poxviruses cause severe diseases, including smallpox and mpox, that pose major threats to human health. The poxvirus core protease (Core

Indexed as

Monkeypox virusViral ProteasesViral ProteinsAldehydesAntiviral AgentsBiocatalysisCatalytic DomainCrystallography, X-RayHumansModels, MolecularOligopeptidesPeptidomimeticsProtease InhibitorsSubstrate SpecificityAldehydesAntiviral AgentsOligopeptidesPeptidomimeticsProtease InhibitorsViral ProteasesViral Proteins

Identifiers

PMID40262633

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.