Evidence map›Paper›PMID 40262559›Full record

ArticleCell adhesion & migration2025

Acyl-CoA dehydrogenase long chain acts as a tumor-suppressive factor in lung adenocarcinoma progression.

Tingju Wei, Guowei Fu, Junjie Zhao, Fengan Cao, Danfeng Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell adhesion & migration, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tingju WeiDepartment of Cardiac Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Guowei FuDepartment of Cardiac Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Junjie ZhaoDepartment of Cardiac Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Fengan CaoDepartment of Respiratory Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Danfeng GuoHenan Key Laboratory for Digestive Organ Transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the role of long-chain acyl-CoA dehydrogenase (ACADL) in lung adenocarcinoma (LUAD). ACADL was significantly downregulated in human LUAD tissues compared to normal lung tissues. In vitro, ectopic expression of ACADL in murine LLC cells decreased cell viability, migration, and invasion, while ACADL knockdown exhibited the opposite effect.

Indexed as

Acyl-CoA Dehydrogenase, Long-ChainAdenocarcinoma of LungDisease ProgressionLung NeoplasmsAnimalsApoptosisCell Line, TumorCell MovementCell ProliferationEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansMiceNeoplasm InvasivenessAcyl-CoA Dehydrogenase, Long-Chainepithelial-mesenchymal transition (EMT)long-chain acyl-CoA dehydrogenase (ACADL)lung cancerTumor biologytumor invasion

Identifiers

PMID40262559
PMCPMC12026206

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.