Evidence map›Paper›PMID 40262547›Full record

ArticleEmerging microbes & infections2025

Risk assessment of 2024 cattle H5N1 using age-stratified serosurveillance data.

Lin-Lei Chen, Xiaojuan Zhang, Kang Zhang, Brian Pui-Chun Chan, Jacqueline Kwan Yuk Yuen, Kwok-Yung Yuen, Pui Wang, Yuhe R Yang, Honglin Chen, Kelvin Kai-Wang To

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lin-Lei ChenState Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.ORCID 0000-0003-4302-5219
Xiaojuan ZhangState Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.ORCID 0009-0008-4783-9184
Kang ZhangCAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology of China, Beijing, People's Republic of China.ORCID 0009-0002-8281-8801
Brian Pui-Chun ChanState Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.ORCID 0000-0002-1361-3346
Jacqueline Kwan Yuk YuenDepartment of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.ORCID 0000-0002-9682-4367
Kwok-Yung YuenState Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Pui WangState Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.ORCID 0000-0003-0745-1130
Yuhe R YangCAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology of China, Beijing, People's Republic of China.ORCID 0000-0003-2321-4653
Honglin ChenState Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.ORCID 0000-0001-5108-8338
Kelvin Kai-Wang ToState Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.ORCID 0000-0002-1921-5824

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The highly pathogenic avian influenza virus A(H5N1) clade 2.3.4.4b has caused a human outbreak in North America since March 2024. Here, we conducted a serosurveillance study to determine the risk of A(H5N1) clade 2.3.4.4b (2024 cattle H5N1) to general population. In the initial screening of 180 serum specimens encompassing all age groups, 2.2% (4/180) had detectable neutralizing antibody (nAb) titres against reverse genetics-derived 2024 cattle H5N1, with all collected from older adults aged ≥60 years old. Further screening showed that 4.2% (19/450) of adults aged ≥60 years old had detectable nAb titres against the 2024 cattle H5N1. 80% (4/5) of serum specimens with nAb titre of ≥40 had detectable Hemagglutination inhibition (HI) titre, and there was a positive correlation between nAb titre and HA binding (r = 0.3325, 95% confidence interval 0.2477-0.4123;

Indexed as

Antibodies, ViralInfluenza A Virus, H5N1 SubtypeInfluenza, HumanOrthomyxoviridae InfectionsAdolescentAdultAgedAged, 80 and overAge FactorsAnimalsAntibodies, NeutralizingCattleChildChild, PreschoolFemaleHemagglutination Inhibition TestsAntibodies, NeutralizingAntibodies, ViralAvian influenza virus H5N1 clade 2.3.4.4bcattleelderlyimmune imprintingserosurveillance

Identifiers

PMID40262547
PMCPMC12064101

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.