Evidence map›Paper›PMID 40262476›Full record

ArticleUltrasonics sonochemistry2025

A vortex-based hydrodynamic cavitation manufacturing platform to generate albumin microbubbles for delivery of chemotherapies to cancerous tumours.

Promita Bhattacharjee, Abhijeet H Thaker, Pratik Kumar Patel, Vivek V Ranade, Sarah P Hudson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasonics sonochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Promita BhattacharjeeDepartment of Chemical Sciences, Bernal Institute, University of Limerick, Ireland.
Abhijeet H ThakerMultiphase Reactors and Intensification Group Bernal Institute, University of Limerick, Limerick V94T9PX, Ireland.
Pratik Kumar PatelDepartment of Chemical Sciences, Bernal Institute, University of Limerick, Ireland.
Vivek V RanadeMultiphase Reactors and Intensification Group Bernal Institute, University of Limerick, Limerick V94T9PX, Ireland; SSPC, The Research Ireland Centre for Pharmaceuticals, University of Limerick, Ireland.
Sarah P HudsonDepartment of Chemical Sciences, Bernal Institute, University of Limerick, Ireland; SSPC, The Research Ireland Centre for Pharmaceuticals, University of Limerick, Ireland. Electronic address: Sarah.Hudson@ul.ie.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel approach was developed to create stable protein-based microbubbles using a vortex-driven hydrodynamic cavitation device. Such microbubbles, tiny gas-filled spheres, combined with ultrasound, can enhance drug uptake leading to inhibition of cancerous cell growth, boosting the effectiveness of anti-cancer drug molecules. The optimal conditions for the fabrication of stable bovine serum albumin (BSA) microbubbles were found to be a 15 wt% bovine serum albumin (BSA) solution at 60 °C with a pH of 6 and an ionic strength of 1.0 M. This resulted in stable BSA microbubbles with an approximate diameter of 7 μm. Curcumin-encapsulated BSA microbubbles (CBMs, 63 ± 1 μM curcumin per 10

Indexed as

Antineoplastic AgentsCurcuminDrug Delivery SystemsHydrodynamicsMicrobubblesSerum Albumin, BovineAnimalsCattleCell Line, TumorDrug LiberationHumansSonicationAntineoplastic AgentsCurcuminSerum Albumin, BovineBreast cancerCavitation deviceCurcuminDrug deliveryMicrobubbles

Identifiers

PMID40262476
PMCPMC12053762

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.