Evidence map›Paper›PMID 40262111›Full record

ArticleJournal of Alzheimer's disease : JAD2025

Cerebrospinal fluid inflammatory cytokines as prognostic indicators for cognitive decline across Alzheimer's disease spectrum.

Elham Ghanbarian, Babak Khorsand, Kellen K Petersen, Bhargav T Nallapu, S Ahmad Sajjadi, Richard B Lipton, Ali Ezzati, Alzheimer's Disease Neuroimaging Initiative *

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Doxycycline: An essential tool for Alzheimer's disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Elham GhanbarianDepartment of Neurology, University of California, Irvine, CA, USA.ORCID 0009-0009-1733-9928
Babak KhorsandDepartment of Neurology, University of California, Irvine, CA, USA.ORCID 0000-0002-1585-3909
Kellen K PetersenDepartment of Neurology, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0003-3195-3456
Bhargav T NallapuSaul B. Korey Department of Neurology, Albert Einstein College of Medicine, New York City, NY, USA.
S Ahmad SajjadiDepartment of Neurology, University of California, Irvine, CA, USA.
Richard B LiptonSaul B. Korey Department of Neurology, Albert Einstein College of Medicine, New York City, NY, USA.
Ali EzzatiDepartment of Neurology, University of California, Irvine, CA, USA.
Alzheimer's Disease Neuroimaging Initiative *

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Vascular Structure and Function in Cognitive AgingP01AG003949 · NIA · YESHIVA UNIVERSITY · PI CAROL A. DERBY · 1985 to 2026
$73.9M
Neuroimaging CoreU19AG076581 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GABRIEL Alejandro DE ERAUSQUIN, Gabriela Gonzalez_Aleman · 2023 to 2026
$32.9M
Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's diseaseR01AG075758 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Charles DeCarli, Hector M Gonzalez · 2022 to 2026
$21.7M
Integrated Care for Chronic Pain and Opioid Use Disorder: The IMPOWR Research Center at Montefiore/Einstein (IMPOWR-ME)RM1DA055437 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI ARNSTEN, JULIA H., BAO, YUHUA · 2021 to 2025
$13.7M
Diagnosis and Risk factors of hippocampal sclerosis of aging and limbic predominant age related TDP-43 encephalopathy; common Alzheimer’s mimicsR01AG062706 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Seyed Ahmad Sajjadi · 2019 to 2026
$9.2M
Validation of the Remote Cognitive Aging and Alzheimer’s Disease REsearch (R-CARE) Toolbox for Diverse PopulationsR01AG080635 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Ali Ezzati, Richard B. LIPTON · 2023 to 2026
$8.6M
Heading and Soccer: Understanding Cognitive Risks, Benefits, and the Potential Mediating Role of White MatterR01NS123374 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Michael Lawrence Lipton · 2022 to 2026
$3.6M
Feasibility and Acceptability of Telephone-delivered MBCT for Migraine and Depression (FATE-MD)R01AT011005 · NCCIH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SENG-TAMACCIO, ELIZABETH K, SHALLCROSS, AMANDA J · 2021 to 2024
$3.1M
COSMIC: An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethno-racial groups and geographical settingsRF1AG057531 · NIA · UNIVERSITY OF NEW SOUTH WALES · PI SACHDEV, PERMINDER S · 2017 to 2020
$2.9M
Sensory Amplifications as Biomarkers of Migraine ProgressionR61NS125153 · NINDS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI BRENNAN, KEVIN CHRISTOPHER · 2023 to 2025
$2.2M
Early and life course socioeconomic adversity and dementia risk in Hispanics/LatinosRF1AG077639 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI DECARLI, CHARLES, GONZALEZ, HECTOR M · 2022 to 2023
$1.9M
FDA HHS UG3 FD006795NCCIH NIH HHS R01 AT011005NIA NIH HHS K23 AG063993NIA NIH HHS P01 AG003949NIA NIH HHS R01 AG062706NIA NIH HHS R01 AG075758NIA NIH HHS R01 AG080635NIA NIH HHS RF1 AG057531NIA NIH HHS RF1 AG077639NIA NIH HHS U01 AG024904NIA NIH HHS U19 AG076581NIDA NIH HHS RM1 DA055437NINDS NIH HHS K23 NS107643NINDS NIH HHS R01 NS123374NINDS NIH HHS R61 NS125153NINDS NIH HHS U24 NS113847
6 · The paper itself

Abstract

BackgroundNeuroinflammation actively contributes to the pathophysiology of Alzheimer's disease (AD); however, the value of neuroinflammatory biomarkers for disease-staging or predicting disease progression remains unclear.ObjectiveTo investigate diagnostic and prognostic utility of inflammatory biomarkers in combination with conventional AD biomarkers.MethodsData from 258 participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI) with cerebrospinal fluid (CSF) biomarkers of amyloid-β (Aβ), tau, and inflammation were analyzed. Clinically meaningful cognitive decline (CMCD) was defined as a ≥ 4-point increase on the Alzheimer's Disease Assessment Scale Cognitive Subscore 11. Predictor variables included demographics (D: age, sex, education),

Indexed as

Alzheimer DiseaseCognitive DysfunctionCytokinesAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersDisease ProgressionFemaleHumansMalePrognosistau ProteinsAmyloid beta-PeptidesBiomarkersCytokinestau ProteinsAlzheimer's diseaseinflammatory biomarkersmachine learningpredictive modeling

Identifiers

PMID40262111
PMCPMC12327883

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.