Evidence map›Paper›PMID 40262025›Full record

ReviewACS synthetic biology2025

The Dawn of High-Throughput and Genome-Scale Kinetic Modeling: Recent Advances and Future Directions.

Ilias Toumpe, Subham Choudhury, Vassily Hatzimanikatis, Ljubisa Miskovic

Abstract readReview
In one paragraph

Review in ACS synthetic biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Advances in Machine Learning Models for Predicting Enzyme Kinetic Parameters.Journal of chemical information and modeling · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ilias ToumpeLaboratory of Computational Systems Biology (LCSB), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne CH-1015, Switzerland.ORCID 0009-0008-6375-3567
Subham ChoudhuryLaboratory of Computational Systems Biology (LCSB), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne CH-1015, Switzerland.
Vassily HatzimanikatisLaboratory of Computational Systems Biology (LCSB), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne CH-1015, Switzerland.ORCID 0000-0001-6432-4694
Ljubisa MiskovicLaboratory of Computational Systems Biology (LCSB), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne CH-1015, Switzerland.ORCID 0000-0001-7333-8211

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Researchers have invested much effort into developing kinetic models due to their ability to capture dynamic behaviors, transient states, and regulatory mechanisms of metabolism, providing a detailed and realistic representation of cellular processes. Historically, the requirements for detailed parametrization and significant computational resources created barriers to their development and adoption for high-throughput studies. However, recent advancements, including the integration of machine learning with mechanistic metabolic models, the development of novel kinetic parameter databases, and the use of tailor-made parametrization strategies, are reshaping the field of kinetic modeling. In this Review, we discuss these developments and offer future directions, highlighting the potential of these advances to drive progress in systems and synthetic biology, metabolic engineering, and medical research at an unprecedented scale and pace.

Indexed as

Models, BiologicalHumansKineticsMachine LearningMetabolic EngineeringSynthetic BiologySystems BiologyDynamical nonlinear systemsGenerative machine learningKinetic models of metabolismKinetic rate lawsSynthetic biologySystems biology

Identifiers

PMID40262025
PMCPMC12362760

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.