ArticleChemical research in toxicology2025
Sex-Specific Formation of 1,2:3,4-Diepoxybutane-Derived Hemoglobin Adducts in 1,3-Butadiene-Exposed Workers.
Nadia I Georgieva, Eric R Siegel, Radim J Šrám, Pamela M Vacek, Vernon E Walker, Richard J Albertini, James A Swenberg, Gunnar Boysen
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In one paragraphArticle in Chemical research in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
8 authors.
Nadia I GeorgievaDepartment of Environmental Health Sciences, University of Arkansas for Medical Sciences, College of Public Health, Little Rock, Arkansas 72205, United States.
Eric R SiegelDepartment of Biostatistics, University of Arkansas for Medical Sciences, College of Medicine, Little Rock, Arkansas 72205, United States.
Radim J ŠrámLaboratory of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR and Health Institute of Central Bohemia, 142 20 Prague 4, Czech Republic.
Pamela M VacekDepartment of Medical Biostatistics (PMV), Robert Larner College of Medicine, University of Vermont, Burlington, Vermont 05405, United States.
Vernon E WalkerDepartment of Pathology and Laboratory Medicine, Robert Larner College of Medicine, University of Vermont, Burlington, Vermont 05405, United States.ORCID 0000-0003-0299-7177 Richard J AlbertiniDepartment of Pathology and Laboratory Medicine, Robert Larner College of Medicine, University of Vermont, Burlington, Vermont 05405, United States.
James A SwenbergDepartment for Environmental Sciences and Engineering, The University of North Carolina at Chapel Hill, Gillings School of Global Public Health, Chapel Hill, North Carolina 27599, United States.
Gunnar BoysenDepartment of Environmental Health Sciences, University of Arkansas for Medical Sciences, College of Public Health, Little Rock, Arkansas 72205, United States.ORCID 0000-0001-8364-9881 Funding
Effects of Genetic Diversity on Carcinogen MetabolismR21ES023046 · NIEHS · UNIV OF ARKANSAS FOR MED SCIS · PI BOYSEN, GUNNAR · 2014 to 2015
$425kA novel approach for quantitation of N-terminal valine adductsR21ES019684 · NIEHS · UNIV OF ARKANSAS FOR MED SCIS · PI BOYSEN, GUNNAR · 2011 to 2012
$405kNIEHS NIH HHS R21 ES019684NIEHS NIH HHS R21 ES023046
6 · The paper itselfAbstract
1,3-Butadiene (BD) is an important industrial chemical that is classified as a human carcinogen. BD carcinogenicity has been attributed to several reactive epoxide metabolites, and the formation of highly mutagenic 1,2:3,4-diepoxybutane (DEB) has been suggested to drive mutagenesis and carcinogenesis at exposures experienced in humans. We report herein the formation of DEB-specific
Indexed as
ButadienesEpoxy CompoundsHemoglobinsOccupational ExposureAdultFemaleHumansMaleMiddle AgedSex Factors1,3-butadieneButadienesdiepoxybutaneEpoxy CompoundsHemoglobins
Identifiers
PMID40261942
PMCPMC13189699
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