ArticleDatabase : the journal of biological databases and curation2025
Mapping assays to the key characteristics of carcinogens to support decision-making.
Article in Database : the journal of biological databases and curation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- AIComet: a reliable automated scoring program for DNA damage assessment in the comet assay.Archives of toxicology · 2026Article
- Evaluating the potential carcinogenic hazard of diisononyl phthalate in humans via systematic integration of human, animal cancer studies, and mechanistic data.Current research in toxicology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The key characteristics (KCs) of carcinogens are the properties common to known human carcinogens that can be used to search for, organize, and evaluate mechanistic data in support of hazard identification. A limiting factor in this approach is that relevant in vitro and in vivo assays, as well as corresponding biomarkers and endpoints, have been only partially documented for each of the 10 KCs (Smith MT, Guyton KZ, Kleinstreuer N et al. The key characteristics of carcinogens: relationship to the hallmarks of cancer, relevant biomarkers, and assays to measure them. Cancer Epidemiol Biomarkers Prev 2020;29:1887-903. https://doi.org/10.1158/1055-9965.EPI-19-1346). To address this limitation, a comprehensive database is described that catalogues these previously described methods and endpoints/biomarkers pertinent to the 10 KCs of carcinogens as well as those referenced as supporting evidence for each KC in the International Agency of Research on Cancer Monograph Volumes 112-131. Our comprehensive mapping of KCs to assays and endpoints can be used to facilitate mechanistic data searches, presents a useful tool for searching for assays and endpoints relevant to the 10 KCs, and can be used to create a roadmap for utilizing data to evaluate the strength of the evidence for each KC. The KC-Assay database is available to the public on the web at https://kcad.cchem.berkeley.edu and acts as a 'living document', with the ability to be updated and refined. Database URL: https://kcad.cchem.berkeley.edu.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.