ArticleCVIR endovascular2025
Micro-CT and histological assessment of renal arterial embolization with Glubran®2 cyanoacrylate: a medium-term follow-up study in a rabbit model.
Article in CVIR endovascular, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Glue Embolus-Induced Portosplenic Thrombosis in Transjugular Intrahepatic Portosystemic Shunt: A Novel Finding During Liver Transplantation.The American journal of case reports · 2026Article
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11 authors.
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Abstract
backgroundCyanoacrylate glues are widely used in interventional radiology as effective embolic agents due to their rapid polymerization and ability to achieve vessel occlusion. Nonetheless, concern remains regarding cast stability and potential recanalization over time. This study used multiple modalities to evaluate the medium-term outcomes of Glubran®2 glue (methacryloxysulfolane and N butyl cyanoacrylate) embolisation in a rabbit renal-artery model.
methodsThe left renal arteries of six rabbits were embolized with 12.5% or 25% Glubran®2. In-vivo micro-CT scans were performed immediately after embolisation (M0) and ex-vivo scans and a histological assessment were done at one month (M1). Magnetic resonance imaging (MRI) was done at M1 to assess arterial occlusion and parenchymal changes. Quantitative and semi-quantitative parameters reflecting glue distribution, cast integrity, and tissue response were analysed. Statistical comparisons used non-parametric tests.
resultsAll six embolisations were completed without complications. Micro-CT at M1 revealed significant cast resorption and fragmentation with both concentrations, but with no evidence of arterial recanalization. MRI and histology confirmed the persistent vascular occlusion with chronic ischemic changes in the renal parenchyma. Compensatory neovascularization from the renal capsule was observed, with no significant differences in histological inflammation between the two concentrations. Glue casts remained within the arterial lumens and were often surrounded by granulomatous inflammation.
conclusionsGlubran®2 was effective for renal artery embolisation, even at a low concentration of 12.5%: despite partial cast resorption, the arteries remained occluded. Micro-CT proved to be a powerful tool for assessing changes in glue casts. Longer-term studies are warranted to further assess vascular remodelling and occlusion durability.
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