Evidence map›Paper›PMID 40261483›Full record

ReviewInfection2025

When oral health affects overall health: biofilms, dental infections, and emerging antimicrobial strategies.

Ahmed Adel Abdelaziz, Ahmed S Doghish, Akram N Salah, Reda M Mansour, Yasser M Moustafa, Sherif S Abdel Mageed, Hebatallah Ahmed Mohamed Moustafa, Walaa A El-Dakroury, Sama A Doghish, Osama A Mohammed and 7 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ahmed Adel AbdelazizFaculty of Dentistry, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Ahmed S DoghishDepartment of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt. ahmed_doghish@azhar.edu.eg.ORCID http://orcid.org/0000-0002-0136-7096
Akram N SalahMicrobiology and Immunology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Reda M MansourZoology and Entomology Department, Faculty of Science, Helwan University, Helwan, Egypt.
Yasser M MoustafaPharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Sherif S Abdel MageedPharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Hebatallah Ahmed Mohamed MoustafaDepartment of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Walaa A El-DakrouryDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Sama A DoghishFaculty of Computer and Information Sciences, Ain Shams University, Cairo, 11566, Egypt.
Osama A MohammedDepartment of Pharmacology, College of Medicine, University of Bisha, Bisha, 61922, Saudi Arabia.
Mustafa Ahmed Abdel-ReheimDepartment of Pharmacology, College of Pharmacy, Shaqra University, Shaqra, 11961, Saudi Arabia. m.ahmed@su.edu.sa.ORCID https://orcid.org/0000-0002-7728-0923
Shaimaa O AbbassFaculty of Dentistry, Ain Shams University, Cairo, 11566, Egypt.
Sara O AbbassFaculty of Dentistry, Modern University for Technology & Information, Cairo, Egypt.
Mariam O AbbassFaculty of Medicine, Ain Shams University, Cairo, 11591, Egypt.
Amira Mohamed SamyFaculty of Dentistry, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Mahmoud A ElrebehyDepartment of Biochemistry, Faculty of Pharmacy, Galala University, New Galala City, Suez, 43713, Egypt.
Youssef A DoghishFaculty of Dentistry, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dental health is a crucial component of overall health, yet it is frequently overlooked in discussions about well-being. This article explores the multifaceted aspects of dental infections, primarily focusing on biofilms formed by pathogenic bacteria such as Streptococcus mutans and Porphyromonas gingivalis. These biofilms contribute to dental caries and periodontal disease, conditions that affect oral health and have systemic consequences. Recent advancements in understanding biofilm formation and interactions have led to novel strategies for prevention and treatment, including using nanoparticles and smart hydrogels designed to disrupt biofilm integrity while promoting biocompatibility with human tissues. Furthermore, the article highlights the potential of natural remedies, including herbal extracts, as adjuncts in maintaining oral hygiene and combating microbial infections. A comprehensive overview of biofilm dynamics, including adhesion, maturation, and dispersion, is presented, alongside discussions on innovative therapeutic approaches addressing the limitations of conventional treatments. Ultimately, this article emphasizes the importance of maintaining dental health in preventing a wide spectrum of health issues, reinforcing that the mouth is a gateway to the body.

Indexed as

Anti-Infective AgentsBiofilmsDental CariesOral HealthPeriodontal DiseasesAnti-Bacterial AgentsHumansPorphyromonas gingivalisStreptococcus mutansAnti-Bacterial AgentsAnti-Infective AgentsBiofilmsDental cariesDental healthNanoparticlesOral bacteriaPeriodontal disease

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.