ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025
Procalcitonin and interleukin- 6 in predicting prognosis of sepsis patients with cancer.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Prognostic Significance of the Prothrombin Time-International Normalized Ratio to Albumin Ratio in Cancer Patients with Complication of Sepsis: A Retrospectively Cohort Study.Shock (Augusta, Ga.) · 2026Article
- Early prediction of sepsis in the ICU: a comparative analysis of multiple machine-learning algorithms using the MIMIC-III database.BMC medical informatics and decision making · 2026Article
- Context-dependent regulation of IL-6 in exercise and colorectal cancer cachexia.Frontiers in oncology · 2026Review
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Abstract
objectiveTo evaluate the ability of infection indicators to predict the prognosis of sepsis patients with tumor.
methodsA total of 317 patients admitted to ICU from January 1, 2021 to June 30, 2021 were enrolled. Among them, 163 patients were infected during peri-operative period, and 98 patients were ultimately diagnosed with sepsis. The infection indicators were analyzed for prediction of sepsis prognosis.
resultsComparison of infection indicators between sepsis and non-sepsis patients showed that procalcitonin (PCT) and interleukin-6 (IL-6) showed significant changes in sepsis patients (p < 0.05), and PCT combined with IL-6 significantly improved the specificity of early screening for sepsis with the highest positivity predictive value for sepsis. A combination of PCT > 5.965 ng/mL and IL-6 > 2808 pg/mL was associated with poor prognosis. Peak value combinations of PCT and IL-6 for prediction specificity, positive predictive value, and negative predictive value were 0.935, 0.692, and 0.682, respectively.
conclusionAbnormal increase of PCT and IL-6 has a good early warning effect on sepsis in cancer patients, and the combination of PCT and IL-6 can improve predictive specificity and increase positive predictive ability of sepsis diagnosis. PCT combined with IL-6 shows the value in predicting the prognosis of sepsis patients with cancer.
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