ArticleVeterinary research communications2025
Infectivity and persistence of bovine leukemia virus in human breast cells: assessing a possible zoonotic link to cancer.
Article in Veterinary research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Article
- Absence of detectable bovine leukemia virus miRNAs in human cancer small RNA-seq datasets.Microbiology spectrum · 2026Article
- Article
- Establishment and Characterization of Human Cell Lines Stably Infected With Bovine Leukemia Virus In Vitro Reveals Apoptosis After Latency and Silencing.Transboundary and emerging diseases · 2026Article
- Host genetic determinants of resistance and susceptibility to bovine leukemia virus infection: A mini-review.Molecular biology reports · 2025Review
- Can Oncogenic Animal Viruses Pose a Threat to Humans?Pathogens (Basel, Switzerland) · 2025Review
- Viral zoonosis and human cancer: a perspective.Infectious agents and cancer · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The study analyzes the potential link between bovine leukemia virus (BLV), an oncogenic retrovirus in cattle, and human breast cancer. BLV infects lymphocytes in cattle, causing persistent infections; while most animals are asymptomatic, some develop lymphosarcoma. The detection of BLV proviral DNA in milk and meat, along with antibodies and proviral DNA in humans, suggests possible zoonotic transmission. In controlled conditions, human mammary epithelial cells (MCF-10 A) were infected with BLV, and the effect of 17-β estradiol (E2) was assessed as a model for natural exposure. BLV integrated its DNA into human cells, increasing the proviral load in the presence of E2, suggesting E2 enhances viral integration. The virus replicated and produced infectious particles capable of infecting bovine mammary cells (MAC-T). Findings suggest BLV could establish infections in human mammary cells under certain conditions, potentially contributing to cancer development. The study highlights the need for further research into its zoonotic potential and emphasizes the importance of food safety practices, particularly regarding raw milk consumption.
Indexed as
Identifiers
40261441What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.