Evidence map›Paper›PMID 40261440›Full record

ArticleNeurosurgical review2025

Substantiated degeneration of rectus capitis posterior minor muscle in Chiari malformation I based on multimodal observations: a prospective cohort study.

Mingbin Bao, Yunsen He, Li Liu, Ye Tao, Qinjiang Huang, Mengjun Zhang, Ping Liu, Zhou Zhang, Yongli Liao, Xiaohong Qin and 2 more

Abstract read
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In one paragraph

Article in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mingbin BaoDepartment of Neurosurgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Yunsen HeDepartment of Neurosurgery, Sichuan Lansheng Brain Hospital & Shanghai Lansheng Brain Hospital Investment Co., Ltd., 6 Anrong Road, Chadianzi Street, Jinniu District, Chengdu, Sichuan, 610036, China.
Li LiuDepartment of Radiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Ye TaoDepartment of Neurosurgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Qinjiang HuangDepartment of Neurosurgery, Wenjiang Hospital of Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Mengjun ZhangDepartment of Neuropsychology, Sichuan Provincial People's Hospital, Sichuan Provincial Center for Mental Health, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Ping LiuDepartment of Neurosurgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Zhou ZhangDepartment of Rehabilitation, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Yongli LiaoDepartment of Neurosurgery, Dechang County Chinese Medicine Hospital, Liangshan Yi Autonomous Prefecture, Chengdu, Sichuan, 615500, China.
Xiaohong QinDepartment of Neuropsychology, Sichuan Provincial People's Hospital, Sichuan Provincial Center for Mental Health, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Wei LiDepartment of Neurosurgery, Sichuan Lansheng Brain Hospital & Shanghai Lansheng Brain Hospital Investment Co., Ltd., 6 Anrong Road, Chadianzi Street, Jinniu District, Chengdu, Sichuan, 610036, China.
Bo WuDepartment of Neurosurgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China. wuboscph@sina.com.

Funding

Health Commission of Chengdu, Jinniu District No. JNKY2024-103Natural Science Foundation of Sichuan Province No. 2023YFS0272Sichuan Medical and Health Care Promotion Institute No. KY2023SJ0231
6 · The paper itself

Abstract

backgroundThe primary pathophysiological mechanism of Chiari Malformation Type I (CMI) is the disruption of cerebrospinal fluid hydrodynamics (CSF-HY) at the craniocervical junction (CVJ), and numerous studies have indicated that the rectus capitis posterior minor (RCPmi) significantly promotes CVJ-CSF-HY. Consequently, RCPmi might have a significant role in the pathophysiological mechanisms underlying CMI, although no relevant studies have been conducted previously. Therefore, this article employs multimodal MRI neuroimaging to investigate the function of RCPmi in CMI patients, while also critically reviewing previous controversies regarding RCPmi research findings in other populations.

methodThis study included a total of 89 subjects, consisting of 45 patients with CMI and 44 healthy controls. Bilateral RCPmi muscle volumes and fatty infiltration (FI) levels were assessed using 3D-MRI-T1 sequences. Simultaneously, diffusion tensor imaging (DTI) data were utilized to extract fractional anisotropy (FA), apparent diffusion coefficient (ADC), as well as the number and length of the muscle fiber tracks. Mann-Whitney U tests, Kruskal-Wallis tests, and independent samples T-tests were conducted to evaluate differences in bilateral RCPmi volume and related metrics between CMI patients and healthy controls. Furthermore, a critical review and summary of all previous research data regarding the morphology of the RCPmi were conducted.

resultThe volume of RCPmi in CMI patients was significantly smaller than that in the healthy control group (p < 0.05), and there was also significant fat infiltration (p < 0.05). The FA, ADC, as well as the number and length of muscle fiber tracks in CMI patients were significantly higher than those in the healthy control group (p < 0.05).

conclusion(1) CMI patients exhibited significant atrophy and FI in bilateral RCPmi compared to healthy controls, and the resulting functional decompensation may affect CVJ-CSF dynamics. (2) The FA and ADC values of the bilateral RCPmi in CMI patients were significantly elevated, suggesting the potential presence of denervation damage. Future research should employ methods such as electromyography, pathology, and molecular biology to validate the pathological and functional impairments of RCPmi and their impact on the normal physiological functions of the craniovertebral junction, aiming to provide new insights for the clinical treatment of CMI.

Indexed as

Arnold-Chiari MalformationNeck MusclesAdolescentAdultCohort StudiesDiffusion Tensor ImagingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMultimodal ImagingProspective StudiesYoung AdultChiari malformationDenervation damageDiffusion tensor imagingFat infiltrationMuscle-dura bridgeRectus capitis posterior minorSyringomyelia

Identifiers

PMID40261440

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.