Evidence map›Paper›PMID 40261426›Full record

Observational studyClinical research in cardiology : official journal of the German Cardiac Society2026

The implementation of a streamlined TAVI patient pathway across five European countries: BENCHMARK registry.

Francesco Saia, Sandra Lauck, Eric Durand, Douglas F Muir, Mark Spence, Mariuca Vasa-Nicotera, David Wood, Cristóbal A Urbano-Carrillo, Damien Bouchayer, Vlad Anton Iliescu and 34 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Clinical research in cardiology : official journal of the German Cardiac Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04579445 (Setting a Benchmark for Resource Utilization and Quality of Care in Patients Undergoing Transcatheter Aortic Valve Implantation in Europe - The BENCHMARK Registry), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04579445 completednot on this map

Setting a Benchmark for Resource Utilization and Quality of Care in Patients Undergoing Transcatheter Aortic Valve Implantation in Europe - The BENCHMARK Registry

Typeobservational_patient_registrySponsorInstitut für Pharmakologie und Präventive MedizinRan2021 to 2024Enrolled2,408ConditionsTranscatheter Aortic Valve Implantation (TAVI)ArmsEducation on tailored Quality Improvement measures
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors.

Francesco SaiaDepartment of Cardiology, Policlinico S. Orsola-Malpighi, University of Bologna, Bologna, Italy.
Sandra LauckCentre for Cardiovascular Innovation, University of British Columbia, Vancouver, BC, Canada.
Eric DurandDepartment of Cardiology, University Hospital of Rouen, Rouen, France.
Douglas F MuirCardiology Department, James Cook University Hospital, Middlesbrough, UK.
Mark SpenceCardiology Department, Mater Private Network, Dublin, Ireland.
Mariuca Vasa-NicoteraCardiology Department, Hospital Sindelfingen-Böblingen, Sindelfingen, Germany.
David WoodCentre for Cardiovascular Innovation, University of British Columbia, Vancouver, BC, Canada.
Cristóbal A Urbano-CarrilloCardiology Department, Hospital Regional Universitario de Málaga, Malaga, Spain.
Damien BouchayerDepartment of Cardiology, The Clinique de L'Infirmerie Protestante, Lyon, France.
Vlad Anton IliescuDepartment of Cardiovascular Surgery, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.
Christophe Saint EtienneDepartment of Cardiology, Centre Hospitalier Regional Universitaire de Tours, Hôpital Trousseau, Tours, France.
Florence LeclercqCardiology Department, Montpellier University Hospital, Montpellier University, Montpellier, France.
Vincent AuffretCHU Rennes Service de Cardiologie, Inserm LTSI U1099, Université de Rennes 1, Rennes, France.
Lluis AsmaratsCardiology Department, Hospital de la Santa Creu I Sant Pau, Instituto de Investigación Biomédica Sant Pau, Barcelona, Spain.
Carlo Di MarioStructural Interventional Cardiology Division, Department of Clinical & Experimental Medicine, Careggi University Hospital, Florence, Italy.
Aurelie VeugeoisDepartment of Cardiology, Institut Mutualiste Montsouris, Paris, France.
Jiri MalyCardiac Center, IKEM Prague, Prague, Czech Republic.
Andreas SchoberDepartment of Cardiology, Hospital Floridsdorf and the Karl Landsteiner Institute for Cardiovascular and Critical Care Research Vienna, 1210, Vienna, Austria.
Luis Nombela-FrancoInstituto Cardiovascular, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
Nikos WernerMedical Department III, Heart Center Trier, Krankenhaus der Barmherzigen Brüder, Trier, Germany.
Joan Antoni Gómez-HospitalHeart Diseases Institute, Bellvitge University Hospital - IDIBELL, L'Hospitalet de Llobregat, University of Barcelona, Barcelona, Spain.
Julia MascherbauerDepartment of Internal Medicine 3/Cardiology, University Hospital St. Pölten, St. Pölten, Austria.
Giuseppe MusumeciCardiology Division, AO Ordine Mauriziano, Turin, Italy.
Nicolas MeneveauCardiology, Besancon Regional University Hospital Center, Besancon, France.
Thibaud MeuriceCardiology, Polyclinique Du Bois, Lille, France.
Felix MahfoudInternal Medicine III, Cardiology, Angiology and Internal Intensive Care Medicine, University Hospital of Saarland, Homburg, Germany.
Federico De MarcoCentro Cardiologico Monzino IRCCS, Milan, Italy.
Tim SeidlerDepartment of Cardiology and Pulmonology, Georg-August-University, Göttingen, Germany.
Florian LeuschnerDepartment of Medicine III, German Centre for Cardiovascular Research (DZHK), University of Heidelberg, Heidelberg, Germany.
Patrick JolyDepartment of Interventional Cardiology, Hôpital Saint Joseph, Marseille, France.
Jean Philippe Collet *Department de Cardiologie, Hôpital de Pitié-Salpêtrière AP-HP, Paris, France.
Ferdinand VogtDepartment for Cardiovascular Surgery, Artemed Klinikum München, Munich, Germany.
Emilio Di LorenzoU.O.C. Cardiologia/UTIC "d. Rotiroti", Department of Cardiology and Cardiovascular Surgery, A.O.R.N. San Giuseppe Moscati Avellino, Avellino, Italy.
Elmar KuhnFaculty of Medicine, Department of Cardiothoracic Surgery, Heart Center, University Hospital of Cologne, Cologne, Germany.
Vicente Peral DisdierCardiology Department, Hospital Universitari Son Espases, Palma, Spain.
Gemma McCalmontEdwards Lifesciences, Prague, Czech Republic.
Radka RakovaEdwards Lifesciences, Prague, Czech Republic.
Wilbert WesselinkEdwards Lifesciences, Prague, Czech Republic.
Jana KurucovaEdwards Lifesciences, Prague, Czech Republic.
Violetta HachaturyanInstitute for Pharmacology and Preventive Medicine, Cloppenburg, Germany.
Claudia M LüskeInstitute for Pharmacology and Preventive Medicine, Cloppenburg, Germany.
Peter BramlageInstitute for Pharmacology and Preventive Medicine, Cloppenburg, Germany.ORCID http://orcid.org/0000-0003-4970-2110
Derk FrankDepartment of Internal Medicine III (Cardiology and Critical Care Medicine), University Clinical Centre Schleswig-Holstein (UKSH), Kiel, Germany. derk.frank@uksh.de.
BENCHMARK Investigator Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBenchmark best practices have been shown to streamline the clinical pathway for patients undergoing transcatheter aortic valve implantation (TAVI), but the impact in diverse health systems is unknown.

aimsWe evaluated the impact of Benchmark best practices implementation in Germany, Austria, France, Spain, and Italy.

methodsInternational, multicentre registry of severe symptomatic aortic stenosis (AS) patients undergoing TAVI with a balloon-expandable valve, before and after Benchmark best practices implementation. Objectives were to reduce overall and intensive care unit (ICU) length of stay (LoS), and to document 30-day safety.

resultsA total of 890 patients were analysed in France, 454 in Spain, 362 in Germany, 300 in Italy, and 176 in Austria. Patients had the highest surgical risk in Germany (EuroSCORE II 6.8 ± 7.3%) and lowest in Spain (3.8 ± 2.6%). Austrian patients reported higher rates of prior myocardial infarction, severe pulmonary hypertension, and aortic valve-related symptoms at baseline. After the implementation of Benchmark best practices, the median hospital LoS was significantly reduced in France (5 vs. 3 days, p < 0.001), Spain (6 vs. 4, p < 0.001), Germany (9 vs. 6, p < 0.001), and Italy (7 vs. 5, p < 0.001); reductions in median ICU LoS were reported in France (1.1 vs. 0 days, p < 0.001), Spain (1.9 vs. 1, p < 0.001), and Germany (1 vs. 0.9, p = 0.004). Across all countries, 30-day safety outcomes were uncompromised and reduced rates of major vascular complications rates were observed in Germany (5.9 vs. 0.0%, p < 0.001).

conclusionThe implementation of Benchmark best practices in diverse European healthcare systems resulted in reduced hospital and ICU LoS without compromising patient safety.

trial registrationClinicalTrials.gov NCT04579445, September 28th, 2020.

Indexed as

Aortic ValveAortic Valve StenosisBenchmarkingCritical PathwaysRegistriesTranscatheter Aortic Valve ReplacementAgedAged, 80 and overEuropeFemaleHumansLength of StayMaleRisk FactorsTreatment OutcomeAortic stenosisClinical careProspective registryQuality of careTAVITranscatheter aortic valve implantation

Identifiers

PMID40261426
PMCPMC13249708

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.