Evidence map›Paper›PMID 40261423›Full record

ArticleArchives of microbiology2025

Formononetin exerts synergistic action with artesunate against multi-drug-resistant P. falciparum arresting ring-to-schizont transition by inducing reactive oxygen species.

Saurabh Kumar, Deepak Singh Kapkoti, Pooja Rani Mina, Ajeet Kumar Verma, Parmanand Kumar, Ramdas, Karuna Shanker, Rajendra Singh Bhakuni, Anirban Pal, Mahendra P Darokar

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Article in Archives of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Saurabh Kumar *Molecular Bioprospection Department, Central Institute of Medicinal and Aromatic Plants (CSIR), Lucknow, 226015, India.
Deepak Singh Kapkoti *Department Medicinal Plant Chemistry Division, Central Institute of Medicinal and Aromatic Plants (CSIR), Lucknow, 226015, India.
Pooja Rani MinaMolecular Bioprospection Department, Central Institute of Medicinal and Aromatic Plants (CSIR), Lucknow, 226015, India.
Ajeet Kumar VermaMolecular Bioprospection Department, Central Institute of Medicinal and Aromatic Plants (CSIR), Lucknow, 226015, India.
Parmanand KumarMolecular Bioprospection Department, Central Institute of Medicinal and Aromatic Plants (CSIR), Lucknow, 226015, India.
RamdasDepartment Medicinal Plant Chemistry Division, Central Institute of Medicinal and Aromatic Plants (CSIR), Lucknow, 226015, India.
Karuna ShankerDepartment Medicinal Plant Chemistry Division, Central Institute of Medicinal and Aromatic Plants (CSIR), Lucknow, 226015, India.
Rajendra Singh BhakuniDepartment Medicinal Plant Chemistry Division, Central Institute of Medicinal and Aromatic Plants (CSIR), Lucknow, 226015, India.
Anirban PalMolecular Bioprospection Department, Central Institute of Medicinal and Aromatic Plants (CSIR), Lucknow, 226015, India.
Mahendra P DarokarMolecular Bioprospection Department, Central Institute of Medicinal and Aromatic Plants (CSIR), Lucknow, 226015, India. mp.darokar@csir.res.in.

Funding

Central Institute of Medicinal and Aromatic Plants HCP007
6 · The paper itself

Abstract

Malaria, caused by Plasmodium falciparum, presents significant challenges for treatment due to the parasite's complex life cycle and increasing multi-drug resistance. Artemisinin-based combination therapies (ACTs) are the current standard treatment, resistance development necessitates the exploration of new therapeutic targets. Recent evidence suggests that targeting oxidative stress to arrest blood stage ring to schizont growth progression in Plasmodium could offer a novel approach to combat drug-resistant malaria. Phytomolecules have been recognized for their potential to modulate oxidative stress with artemisinin derivatives. In the present study, we aimed to evaluate the effectiveness of formononetin (FMT), a natural isoflavonoid, alone and in combination with artesunate (ART) against multidrug-resistant P. falciparum (K1) strain and to decipher the underlying mechanism of action. The study presents compelling evidence demonstrating the anti-plasmodial action of FMT alone (IC

Indexed as

AntimalarialsArtemisininsArtesunateDrug Resistance, MultipleIsoflavonesPlasmodium falciparumReactive Oxygen SpeciesSchizontsDrug SynergismHumansMalaria, FalciparumOxidative StressAntimalarialsArtemisininsArtesunateformononetinIsoflavonesReactive Oxygen SpeciesAnti-plasmodial activityArtesunateFormononetinReactive oxygen speciesSynergy

Identifiers

PMID40261423

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.