SynthesisPediatric surgery international2025
Systematic review and meta-analysis on macrovascular and microvascular anatomy of preputial skin in hypospadias and its implications.
Synthesis in Pediatric surgery international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Prospective microvessel density profiling across severity of hypospadias: understanding preputial tissue angiogenic deficit and the impact of preoperative testosterone stimulation.Pediatric surgery international · 2026Observational
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHypospadias repair is challenging due to complications like urethrocutaneous fistula and flap necrosis, often linked to preputial vascular anatomy. While macrovascular and microvascular patterns are studied, findings are inconsistent. The impact of preoperative hormonal therapy (PHT) on vascularity and outcomes is unclear. This review and meta-analysis evaluates preputial vascular anatomy in hypospadias and its surgical implications.
methodsA systematic review (2000-2024) was conducted in PubMed, MEDLINE, and Cochrane following PRISMA guidelines. The inclusion criteria used the PICOS framework. The bias was assessed using Robvis and microvessel density (MVD) differences were analyzed via meta-analysis with heterogeneity quantified (I
resultsFourteen studies (707 hypospadias, 106 controls) revealed predominant net-like vascular patterns in severe cases. MVD was significantly lower in hypospadias (pooled Mean, 28.85/HPF) versus controls (pooled Mean, 45.46/HPF), correlating with severity of hypospadias, the MVD varied a lot across different population worldwide. The meta-analysis showed high heterogeneity (I
conclusionHypospadias alters preputial vascular anatomy, show varied patterns, with reduced MVD linked to surgical challenges. A lot of variation exist in MVD across various population. PHT enhances vascularity but requires further validation. Standardized vascular assessments and advanced imaging are essential for optimizing surgical outcomes. PROSPERO registration number CRD42025640297.
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Registered trials
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