Evidence map›Paper›PMID 40261367›Full record

ArticleJournal of neurology2025

Global, regional, and national epidemiology of ischemic stroke in young adults, 1990-2021.

Mingli He, Shun Zhang, Xun Liu, Yanan He, Xinru Gu, Chaoyan Yue

Abstract read
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In one paragraph

Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mingli He *The First People'S Hospital of Lianyungang, Xuzhou Medical University, Lianyungang, 222001, Jiangsu, China.
Shun Zhang *The First People'S Hospital of Lianyungang, Xuzhou Medical University, Lianyungang, 222001, Jiangsu, China.ORCID http://orcid.org/0009-0000-3142-5026
Xun LiuThe First People'S Hospital of Lianyungang, Xuzhou Medical University, Lianyungang, 222001, Jiangsu, China.
Yanan HeDepartment of Computer Sciences, Purdue University, West Lafayette, IN, USA.
Xinru GuThe First People'S Hospital of Lianyungang, Xuzhou Medical University, Lianyungang, 222001, Jiangsu, China. xinrugu0828@163.com.
Chaoyan YueObstetrics and Gynecology Hospital of Fudan University, Fang Xie Road, No. 419, Shanghai, 200090, China. 20111250007@fudan.edu.cn.

Funding

Institute of Medicinal Plant Development KD2024KYJJ018
6 · The paper itself

Abstract

introductionThis study, for the first time, utilizes the 2021 GBD data to analyze the disease burden of ischemic stroke in young adults (defined as aged 20-50 years) globally, aiming to provide a scientific basis for public health interventions.

methodsThe study employs GBD data from 1990 to 2021 to analyze the incidence, mortality, and disability-adjusted life years (DALYs) of ischemic stroke in young adults. We assess differences in disease burden across regions with varying levels of socioeconomic development using the Sociodemographic Index (SDI). We also utilize Joinpoint regression and the Bayesian Age-Period-Cohort (BAPC) model to analyze temporal trends and predict future burdens. Additionally, we examine the distribution of ischemic stroke in young adults across different ages, genders, and regions.

resultsIn 2021, the number of deaths and incidences increased; however, the age-standardized mortality rate decreased. The Middle SDI region had the highest number of deaths and incidence, while the High SDI region had the lowest number of deaths. Southeast Asia had the highest estimated annual percentage change (EAPC) in mortality Age-Standardized Rate (ASR), East Asia had the highest EAPC in incidence ASR. The incidence was highest in the age group of 40-49 years, with a shift from older to middle-aged populations. The mortality rate in males was generally higher than in females. The age-standardized incidence rate of ischemic stroke in young adults is expected to continue declining in the future, while the number of cases is likely to keep increasing.

conclusionDespite a global decline of mortality and incidence in all SDI regions, the disease burden continues to rise due to population growth and aging, especially in Middle SDI regions. The study predicts ongoing increases in disease burden, highlighting the impact of gender and socioeconomic factors. Further research is needed to prevent the disease from affecting younger populations.

Indexed as

Global HealthIschemic StrokeAdultDisability-Adjusted Life YearsFemaleHumansIncidenceMaleMiddle AgedYoung AdultGlobal Burden of DiseaseIschemic strokeTrends analysisYoung adults

Identifiers

PMID40261367

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.