Evidence map›Paper›PMID 40261353›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Sequential administration of febuxostat and vitamin E protects against testicular ischemia/reperfusion injury via inhibition of sperm DNA damage in Wistar rats.

Richard Adedamola Ajike, Oladele Ayobami Afolabi, Babatunde Adebola Alabi, Ayodeji Folorunsho Ajayi, Olubunmi Simeon Oyekunle, Sodiq Kolawole Lawal, Samuel Oluwaseun Olojede, Okot-Asi Nku-Ekpang, Oluwaseun Samuel Hezekiah, Opeyemi Sodiq Hammed

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Richard Adedamola AjikeDepartment of Physiology, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
Oladele Ayobami AfolabiDepartment of Physiology, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria. aoafolabi59@lautech.edu.ng.ORCID http://orcid.org/0000-0003-2461-8035
Babatunde Adebola AlabiDepartment of Pharmacology & Therapeutics, Bowen University, Iwo, Osun State, Nigeria.
Ayodeji Folorunsho AjayiDepartment of Physiology, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
Olubunmi Simeon OyekunleDepartment of Physiology, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
Sodiq Kolawole LawalSchool of Nursing, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana.
Samuel Oluwaseun OlojedeDepartment of Human Biology, Faculty of Health Sciences, Walter Sisulu University, Mthatha, South Africa.
Okot-Asi Nku-EkpangDepartment of Physiology, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria.
Oluwaseun Samuel HezekiahDepartment of Physiology, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
Opeyemi Sodiq HammedDepartment of Physiology, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathway of testicular ischemia-reperfusion injury (TIRI) has been shown to involve reactive oxygen species (ROS) generation in the ischemic phase and later phase of reperfusion. This study was therefore designed to investigate the effect of blockage of ROS in the ischemic and reperfusion phases of TIRI. Thirty male Wistar rats were grouped into five groups (n = 6 rats each): sham, torsion + detorsion (TD), febuxostat (FEB)-administered (TFD) group, vitamin E (V)-administered (TDV) group, and FEB and vitamin E-administered (TFDV) group. Blood samples (for inflammatory and hormonal assay), testicular (for oxidative stress and histopathology), and epididymal (for sperm DNA damage and indices) tissues were collected after 3 days of detorsion. The TFD and TFDV groups showed a significant reduction in XO and MDA (p < 0.001; η

Indexed as

AntioxidantsDNA DamageFebuxostatReperfusion InjurySpermatozoaTestisVitamin EAnimalsMaleOxidative StressRatsRats, WistarReactive Oxygen SpeciesSpermatic Cord TorsionAntioxidantsFebuxostatReactive Oxygen SpeciesVitamin EFebuxostatReactive oxygen speciesTesticular ischemia–reperfusion injury

Identifiers

PMID40261353

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.