Evidence map›Paper›PMID 40261350›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2025

Alternative medicines in oncology: a focus on natural products against gastric cancer.

Ahmed S Doghish, Mohamed Bakr Zaki, Abdulrahman Hatawsh, Nourhan Elfar, Nora A A Alhamshry, Mai A Abd-Elmawla, Nora M Aborehab, Abdullah F Radwan, Rewan Moussa, Sherif S Abdel Mageed and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ahmed S DoghishDepartment of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Mohamed Bakr ZakiDepartment of Biochemistry, Faculty of Pharmacy, University of Sadat City, Sadat City, 32897, Egypt.
Abdulrahman HatawshBiotechnology School, Nile University, 26th of July Corridor, Sheikh Zayed City, Giza, 12588, Egypt.
Nourhan ElfarSchool of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, New Administrative Capital, Cairo, 11578, Egypt.
Nora A A AlhamshryDepartment of Biochemistry, Faculty of Pharmacy, University of Sadat City, Sadat City, 32897, Egypt.
Mai A Abd-ElmawlaDepartment of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Nora M AborehabDepartment of Biochemistry, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt.
Abdullah F RadwanDepartment of Pharmacy, Kut University College, Al Kut, Wasit, 52001, Iraq.
Rewan MoussaFaculty of Medicine, Helwan University, Cairo, 11795, Egypt.
Sherif S Abdel MageedPharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Mustafa Ahmed Abdel-ReheimDepartment of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra, 11961, Saudi Arabia. m.ahmed@su.edu.sa.
Osama A MohammedDepartment of Pharmacology, College of Medicine, University of Bisha, Bisha, 61922, Saudi Arabia.
Hanan ElimamDepartment of Biochemistry, Faculty of Pharmacy, University of Sadat City, Sadat City, 32897, Egypt. Hanan.Elimam@fop.usc.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is justification for optimism about the potential contribution of alternative medicines to cancer management, which now ranks as the second leading cause of death globally. Primary carcinogens arise from several sources, including agriculture, industry, and dietary intake. Gastric cancer (GC) significantly affects an individual's health due to its classification as a malignant tumor associated with elevated mortality and morbidity rates. Chemotherapy is now widely regarded as the gold standard for treating GC. Chemotherapy, however, exerts significant detrimental effects on human health, including irreversible damage to multiple organs. Consequently, it is essential to employ innovative strategies for cancer prevention. Natural products are now the focus of intensive study due to their efficacy against cancer and low toxicity levels. Natural compounds have shown a diverse range of anti-cancer properties. This review aims to emphasize studies on natural compounds that inhibit metastasis, induce apoptosis in GC, and decrease cellular proliferation. All the natural compounds from different sources were incorporated in this review not only medicinal plants derived compounds. This review aims to examine a comprehensive array of natural therapies that may enhance human health and facilitate GC prevention without inducing discernible negative effects. Moreover, this review aims to discuss the toxic side effects of phytochemicals and shed light on mechanisms underlying the action of potential natural products against GC. This review offers a novel perspective by integrating a broad spectrum of natural compounds from diverse sources, not limited to medicinal plants, to explore their anti-cancer properties against gastric cancer.

Indexed as

Antineoplastic Agents, PhytogenicBiological ProductsComplementary TherapiesStomach NeoplasmsAnimalsHumansAntineoplastic Agents, PhytogenicBiological ProductsGastric cancerNatural productsPhytochemicals

Identifiers

PMID40261350

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.